Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: analysis of the apparent diffusion coefficient value.
Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: analysis of the apparent diffusion coefficient value.
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DOI：
10.2463/mrms.3.79
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发表时间：
2004-07-15
期刊：
影响因子：
--
通讯作者：
Nawano, Shigeru
中科院分区：
文献类型：
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作者：
Kuroki, Yoshifumi;Nasu, Katsuhiro;Nawano, Shigeru
目的：弥散加权成像(DWI)在神经放射学领域的应用已经确立。尽管DWI具有较高的对比度分辨率，但存在磁化率伪影和化学位移伪影的缺点。采用敏感性编码(SENSE)技术对乳腺癌进行弥散加权成像。方法：60例女性乳腺肿块患者。所有患者均行MRI检查，包括SENSE-DWI，并经组织学确诊。在这些患者中，55人被诊断为乳腺癌，其余5人被诊断为良性肿块。组织学诊断：浸润性导管癌(IDC)39例，以导管内成分为主的IDC和非IDC(单纯或显性NIDC)11例，特殊类型癌5例。使用的MR系统是Gyrocan Intera 1.5T(飞利浦医疗系统)。除了常规的乳腺癌MRI，包括对比剂增强的动态增强，还获得了SENSE-DWI。将SENSE-DWI图像的位置信息的准确性与常规图像的位置信息的准确性进行了视觉比较。用SENSE-DWI软件分析乳腺肿块的表观弥散系数(ADC)值。结果：位置信息的准确性足以满足所有患者的诊断要求。乳腺癌的ADC值为1.021×10~(-3)mm~2/S，良性肿块的ADC值为1.488×10~(-3)mm~2/S(p=0.0002)。IDC的平均ADC值为0.968×10~(-3)mm~2/S，单纯乳腺IDC的ADC值为1.218×10~(-3)mm~2/S(p=0.0011)。结论：SENSE-DWI对乳腺肿块的诊断具有足够的价值。SENSE-DWI可以获得更多有关病变的详细信息，包括肿瘤细胞密度，这是传统技术难以获得的。
PURPOSE: The usefulness of diffusion-weighted imaging (DWI) in the field of neuroradiology has been established. Despite its high contrast resolution, DWI has the disadvantages of susceptibility artifact and chemical shift artifact. We performed DWI of breast cancer with the sensitivity encoding (SENSE) technique.METHODS: The subjects were 60 female patients with breast mass. All patients underwent MRI including SENSE-DWI and were diagnosed histologically. Of these patients, 55 were diagnosed with breast cancer and the remaining five were diagnosed with benign mass. The histological diagnoses of breast cancer were as follows: 39 cases of invasive ductal carcinoma (IDC); 11 cases of IDC with a predominant intraductal component and non IDC (pure or predominant NIDC); and five cases of special types of cancer. The MR system used was a Gyroscan Intera 1.5T (Philips Medical Systems). In addition to routine MRI for breast cancer, including contrast-enhanced dynamic, SENSE-DWI was obtained. The accuracy of the positional information of SENSE-DWI was visually compared with that of conventional images. The apparent diffusion coefficient (ADC) values of breast mass were analyzed with SENSE-DWI.RESULTS: The accuracy of positional information was adequate for diagnosing of all patients. The mean ADC value of breast cancer was 1.021x10(-3) mm2/s and that of benign mass was 1.488x10(-3) mm2/s (p=0.0002). The mean ADC value of IDC was 0.968x10(-3) mm2/s and that of pure or predominant NIDC was 1.218x10(-3) mm2/s (p=0.0011).CONCLUSION: SENSE-DWI was of sufficient quality to support diagnosis of breast mass. SENSE-DWI may permit the acquisition of more detailed information about lesions, including tumor cellularity, that is difficult to obtain with conventional techniques.