A randomized trial of patching regimens for treatment of moderate amblyopia in children.
A randomized trial of patching regimens for treatment of moderate amblyopia in children.
复制标题
DOI：
10.1001/archopht.121.5.603
复制
发表时间：
2003-05
影响因子：
--
通讯作者：
M. Repka;R. Beck;J. Holmes;E. Birch;D. Chandler;S. Cotter;R. Hertle;R. Kraker;P. Moke;G. Quinn-G
中科院分区：
文献类型：
--
作者：
M. Repka;R. Beck;J. Holmes;E. Birch;D. Chandler;S. Cotter;R. Hertle;R. Kraker;P. Moke;G. Quinn-G
目的 比较 2 小时与 6 小时每日遮盖治疗 7 岁以下儿童中度弱视的效果。方法 在一项随机多中心（35 个中心）临床试验中，189 名 7 岁以下弱视范围为 20/40 至 20/80 的儿童被分配接受每天 2 小时或 6 小时的遮盖，并在遮盖期间每天至少进行 1 小时的近视活动。 主要结果测量 4 个月后弱视眼的视力。结果 两组弱视眼的视力提高程度相似。从基线到 4 个月，每组弱视眼的视力平均提高 2.40 行 (P =.98)。每组 62% 的患者 4 个月视力至少为 20/32 和/或较基线提高 3 行或更多 (P>.99)。结论 在治疗 3 至 7 岁儿童的中度弱视时，每天 2 小时的遮盖与 1 小时的近视活动相结合可产生与每天 6 小时的遮盖治疗所产生的视力改善相似的程度。
OBJECTIVE To compare 2 hours vs 6 hours of daily patching as treatments for moderate amblyopia in children younger than 7 years. METHODS In a randomized multicenter (35 sites) clinical trial, 189 children younger than 7 years with amblyopia in the range of 20/40 to 20/80 were assigned to receive either 2 hours or 6 hours of daily patching combined with at least 1 hour per day of near visual activities during patching.Main Outcome Measure Visual acuity in the amblyopic eye after 4 months. RESULTS Visual acuity in the amblyopic eye improved a similar amount in both groups. The improvement in the visual acuity of the amblyopic eye from baseline to 4 months averaged 2.40 lines in each group (P =.98). The 4-month visual acuity was at least 20/32 and/or improved from baseline by 3 or more lines in 62% of patients in each group (P>.99). CONCLUSION When combined with prescribing 1 hour of near visual activities, 2 hours of daily patching produces an improvement in visual acuity that is of similar magnitude to the improvement produced by 6 hours of daily patching in treating moderate amblyopia in children aged 3 to 7 years.