Decreased incidence of thymic lymphoma in AKR mice as a result of chronic, fractionated low-dose total-body X irradiation
Decreased incidence of thymic lymphoma in AKR mice as a result of chronic, fractionated low-dose total-body X irradiation
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DOI：
10.2307/3579560
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发表时间：
1996-11-01
影响因子：
3.4
通讯作者：
Sakamoto, K
中科院分区：
文献类型：
--
作者：
Ishii, K;Hosoi, Y;Sakamoto, K
我们研究了低剂量全身X射线照射是否能抑制AKR小鼠淋巴瘤的发展。雄性小鼠从11周龄开始接受5cGy每周三次或15 cGy每周两次的照射，持续40周。假照射组淋巴瘤发生率为80.5%，每周3次5cGy照射组淋巴瘤发生率为67.5%，每周2次15 cGy照射组淋巴瘤发生率为48.6%。每周2次15 cGy照射组淋巴瘤发生率明显降低（P = 0.006）。平均存活时间从对照组小鼠的283 +/- 3天显著延长到每周两次15 cGy照射的小鼠的316 +/- 10天（P = 0.008）和每周三次5 cGy照射的小鼠的309 +/- 14天（P = 0.040）。由于约80%的雄性AKR小鼠死于淋巴瘤，因此在受辐射小鼠中观察到的寿命延长可能是由于淋巴瘤发病率降低。(C)1996年，辐射研究学会
We have investigated whether low-dose total-body X irradiation could suppress the development of lymphoma in AKR mice. Male mice were irradiated with 5 cGy three times a week or 15 cGy two times a week from 11 weeks of age for 40 weeks. The incidences of lymphoma were 80.5% in sham-irradiated mice, 67.5% in mice irradiated with 5 cGy three times a week and 48.6% in mice irradiated with 15 cGy twice a week. Incidence of lymphoma was significantly reduced by irradiation with 15 cGy twice a week (P = 0.006). The mean survival time was significantly prolonged from 283 +/- 3 days in control mice to 316 +/- 10 days in mice irradiated with 15 cGy twice a week (P = 0.008) and to 309 +/- 14 days in mice irradiated with 5 cGy three times a week (P = 0.040). Because about 80% of male AKR mice die of lymphoma, it is likely that the prolonged life span observed in the irradiated mice is due to the reduced incidence of lymphoma. (C) 1996 by Radiation Research Society