Place cells in the hippocampus: Eleven maps for eleven rooms
Place cells in the hippocampus: Eleven maps for eleven rooms
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DOI：
10.1073/pnas.1421056111
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发表时间：
2014-12-30
影响因子：
11.1
通讯作者：
Moser, May-Britt
中科院分区：
文献类型：
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作者：
Alme, Charlotte B.;Miao, Chenglin;Moser, May-Britt
海马体回路对高容量情景记忆的贡献通常归因于存储在这些网络中的大量正交活动模式。然而，海马体具有高容量存储能力的证据尚不清楚。当动物在成对的环境中进行测试时，不同的位置细胞组合被招募，与独立表征的概念一致。然而，表征在更大数量的环境中保持独立的程度尚未确定。为了研究当动物暴露在多种环境中时，空间放电模式是否会复发，我们在11个记录盒中对老鼠进行了测试，每个记录盒都在不同的房间里，允许每只动物进行55次地点地图比较。在每种环境下，记录海马区CA3神经元群的活动，平均每只动物有30个活跃细胞。表征在同一房间的重复测试之间高度相关，但在不同房间的所有组合中保持正交，来自每个环境的活性细胞样本的重叠最小。在许多房间中有少量细胞有活动，但这些细胞的放电位置完全不相关。综上所述，结果表明，存储在海马区CA3的独立空间表征的数量很大，在不同环境下空间放电模式的重复很少。
The contribution of hippocampal circuits to high-capacity episodic memory is often attributed to the large number of orthogonal activity patterns that may be stored in these networks. Evidence for high- capacity storage in the hippocampus is missing, however. When animals are tested in pairs of environments, different combinations of place cells are recruited, consistent with the notion of independent representations. However, the extent to which representations remain independent across larger numbers of environments has not been determined. To investigate whether spatial firing patterns recur when animals are exposed to multiple environments, we tested rats in 11 recording boxes, each in a different room, allowing for 55 comparisons of place maps in each animal. In each environment, activity was recorded from neuronal ensembles in hippocampal area CA3, with an average of 30 active cells per animal. Representations were highly correlated between repeated tests in the same room but remained orthogonal across all combinations of different rooms, with minimal overlap in the active cell samples from each environment. A low proportion of cells had activity in many rooms but the firing locations of these cells were completely uncorrelated. Taken together, the results suggest that the number of independent spatial representations stored in hippocampal area CA3 is large, with minimal recurrence of spatial firing patterns across environments.