Anticancer effects of adriamycin-loaded hydroxyapatite implants determined in a Swarm rat chondrosarcoma model.
Anticancer effects of adriamycin-loaded hydroxyapatite implants determined in a Swarm rat chondrosarcoma model.
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在 Swarm 大鼠软骨肉瘤模型中确定负载阿霉素的羟基磷灰石植入物的抗癌作用。
DOI：
10.1254/jjp.65.289
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
T. Nabeshima
中科院分区：
文献类型：
--
作者：
K. Yamamura;H. Iwata;T. Osada;T. Yotsuyanagi;T. Nabeshima
我们研究了负载阿霉素 (ADR) 的羟基磷灰石 (HAP) 珠在 Swarm 大鼠软骨肉瘤模型中的抗肿瘤作用。当将一颗载有ADR的HAP珠（ADR：0.8毫克/珠）植入大鼠肿瘤的中心部分时，载有ADR的HAP珠显示出良好的治疗效果，将寿命（ILS）延长了90%。值得注意的是，没有观察到白细胞减少和腹泻。这些结果表明 HAP 递送提供了一种有趣且潜在有效的方法。
We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.