Early invasive cervical cancer: CT and MR imaging in preoperative evaluation-ACRIN/GOG comparative study of diagnostic performance and Interobserver variability
Early invasive cervical cancer: CT and MR imaging in preoperative evaluation-ACRIN/GOG comparative study of diagnostic performance and Interobserver variability
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DOI：
10.1148/radiol.2452061983
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发表时间：
2007-11-01
期刊：
影响因子：
19.7
通讯作者：
Mitchell, Donald G.
中科院分区：
文献类型：
--
作者：
Hricak, Hedvig;Gatsonis, Constantine;Mitchell, Donald G.
目的：以手术病理结果为参考标准，回顾性比较计算机断层扫描 (CT) 和磁共振 (MR) 成像在早期浸润性宫颈癌治疗前评估中的诊断表现和观察者间差异。 材料和方法：这项符合 HIPAA 的研究获得了机构审查委员会的批准和知情同意，用于评估 156 名女性（中位年龄 43 岁）的术前 CT (n = 146) 和/或 MR 成像 (n = 152) 研究。年龄；范围，22 - 81 岁）来自美国放射成像网络学院和妇科肿瘤学小组之前的一项前瞻性多中心研究，该研究对 172 名经活检证实患有宫颈癌（临床分期 >= IB）的女性进行了研究。四名放射科医生（经验，7 - 15 年）解释了 CT 扫描，四名放射科医生（经验，12 - 20 年）回顾性地解释了 MR 研究。使用受试者操作特征曲线评估肿瘤可视化和宫旁侵犯检测（P = IIB），敏感性为 0.14 - 0.38 和 0.40 - 0.57，阳性预测值（PPV）为 0.38 - 1.00 和 0.32 - 0.39，特异性为 0.84 - 1.00 和 0.77 - 0.80，阴性预测值 (NPV) 为 0.81 - 0.84 和 0.83 - 0.87。 MR 成像在肿瘤可视化方面明显优于 CT（P
Purpose: To retrospectively compare diagnostic performance and interobserver variability for computed tomography ( CT) and magnetic resonance ( MR) imaging in the pretreatment evaluation of early invasive cervical cancer, with surgical pathologic findings as the reference standard.Materials and Methods: This HIPAA- compliant study had institutional review board approval and informed consent for evaluation of preoperative CT ( n = 146) and/ or MR imaging ( n = 152) studies in 156 women ( median age, 43 years; range, 22 - 81 years) from a previous prospective multicenter American College of Radiology Imaging Network and Gynecologic Oncology Group study of 172 women with biopsy- proved cervical cancer ( clinical stage >= IB). Four radiologists ( experience, 7 - 15 years) interpreted the CT scans, and four radiologists ( experience, 12 - 20 years) interpreted the MR studies retrospectively. Tumor visualization and detection of parametrial invasion were assessed with receiver operating characteristic curves ( with P = IIB), sensitivities were 0.14 - 0.38 and 0.40 - 0.57, positive predictive values ( PPVs) were 0.38 - 1.00 and 0.32 - 0.39, specificities were 0.84 - 1.00 and 0.77 - 0.80, and negative predictive values ( NPVs) were 0.81 - 0.84 and 0.83 - 0.87. MR imaging was significantly better than CT for tumor visualization ( P