Lyme disease of the brainstem
Lyme disease of the brainstem
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DOI：
10.1007/s00234-005-1440-2
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发表时间：
2005-12-01
期刊：
影响因子：
2.8
通讯作者：
Halperin, JJ
中科院分区：
文献类型：
--
作者：
Kalina, P;Decker, A;Halperin, JJ
莱姆病是由壁虱传播的伯氏疏螺旋体引起的一种多系统传染病。中枢神经系统(CNS)受累通常会引起局部炎症，最常见的是脑膜炎，但很少有脑实质受累。我们描述了一位患者，其临床表现提示为脑干突起。磁共振成像(MRI)和正电子发射断层扫描(PET)提示脑干肿瘤。在活检之前，实验室评估导致莱姆病的诊断。抗菌治疗后，临床和影像异常明显改善。我们描述的莱姆病受累的小脑脚与高代谢的PET。虽然MRI是大多数疑似中枢神经系统病变的主要成像手段，但PET的实际应用仍在不断扩大。
Lyme disease is a multisystem infectious disease caused by the tick-borne spirochete, Borrelia burgdorferi. Central nervous system (CNS) involvement typically causes local inflammation, most commonly meningitis, but rarely parenchymal brain involvement. We describe a patient who presented with clinical findings suggesting a brainstem process. Magnetic resonance imaging (MRI) and positron emission tomography (PET) suggested a brainstem neoplasm. Prior to biopsy, laboratory evaluation led to the diagnosis of Lyme disease. Clinical and imaging abnormalities improved markedly following antimicrobial therapy. We describe Lyme disease involvement of the cerebellar peduncles with hypermetabolism on PET. Although MRI is the primary imaging modality for most suspected CNS pathology, the practical applications of PET continue to expand.