Helicobacter pylori Seropositivity Is Associated with Gastric Cancer Regardless of Tumor Subtype in Korea
Helicobacter pylori Seropositivity Is Associated with Gastric Cancer Regardless of Tumor Subtype in Korea
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DOI：
10.5009/gnl.2010.4.4.466
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发表时间：
2010-12-01
期刊：
影响因子：
3.4
通讯作者：
Park, Young-lee
中科院分区：
文献类型：
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作者：
Cho, Soo-Jeong;Choi, Il Ju;Park, Young-lee
背景/目的：根据韩国的肿瘤亚型，评估幽门螺杆菌感染与胃癌(GC)的关系。方法：采用酶联免疫吸附试验检测幽门螺杆菌感染状况。总共有2819名GC患者和562名健康对照被研究。在调整了可能的混杂因素后，使用了Logistic回归方法。结果：胃癌组幽门螺杆菌感染率(84.7%)显著高于对照组(66.7%)(优势比[OR]3.13；95%可信区间[CI]2.46~3.97)。年龄在60岁的幽门螺杆菌感染者调整后的OR显著高于60岁(OR，1.48；95%CI，0.88-2.46；p
Background/Aims: To evaluate the association between Helicobacter pylori (H. pylon) infection and gastric cancer (GC) according to tumor subtype in Korea. Methods: H. pylori status was determined serologically using the enzyme-linked immunosorbent assay. In total, 2,819 patients with GC and 562 healthy controls were studied. A logistic regression method was used after adjusting for possible confounders. Results: The prevalence of H. pylori infection was significantly higher in the GC patients (84.7%) than in the controls (66.7%) (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.46-3.97). The adjusted OR was significantly higher in H.-pylori-infected patients aged = 60 years (OR, 1.48; 95% Cl, 0.88-2.46; p