Vitamin D deficiency and risk of cardiovascular diseases: a narrative review.
Vitamin D deficiency and risk of cardiovascular diseases: a narrative review.
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DOI：
10.1186/s40885-018-0094-4
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发表时间：
2018
影响因子：
4.2
通讯作者：
Bachuwa G
中科院分区：
文献类型：
--
作者：
Kheiri B;Abdalla A;Osman M;Ahmed S;Hassan M;Bachuwa G
维生素D是一种脂溶的前激素，通过与维生素D受体(VDR)的相互作用，在许多生理过程中发挥着广泛的调节作用。它在骨骼和钙代谢中发挥着重要作用。维生素D缺乏并不少见，它与许多与健康有关的问题有关，包括骨骼和非骨骼并发症。低维生素D与心血管疾病和危险因素的关系已经在动物和人类研究中进行了探索。然而，关于补充维生素D对心血管危险因素和高血压的影响的研究和试验结果相互矛盾。因此，大型、有效的随机对照试验是有必要的。如果成功，补充简单和低成本的维生素D可以对我们的健康产生积极的影响。在这里，我们总结了维生素D、心血管疾病和危险因素相关的证据，包括冠状动脉疾病、中风和高血压，以及死亡率，特别是顽固性高血压。
Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR). It plays a major role in bones and calcium metabolism. Vitamin D deficiency is not uncommon and it has been associated with many health-related issues, including skeletal and non-skeletal complications. The association of low vitamin D and cardiovascular diseases and risk factors has been explored in both animal and human studies. However, studies and trials on the effect of vitamin D supplementation on cardiovascular risk factors and hypertension are conflicting with inconsistent results. Therefore, large, well-powered randomized controlled trials are warranted. If successful, supplementation with easy and low-cost vitamin D can impact our health positively. Here, we summarized the evidence for the association of vitamin D, cardiovascular diseases and risk factors, including coronary artery diseases, stroke, and hypertension, and mortality, with special consideration to resistant hypertension.