Detection of miR-106a in gastric carcinoma and its clinical significance
Detection of miR-106a in gastric carcinoma and its clinical significance
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DOI：
10.1016/j.cca.2008.10.021
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发表时间：
2009-02-01
影响因子：
5
通讯作者：
Zhong, Jiuchang
中科院分区：
文献类型：
--
作者：
Xiao, Bingxiu;Guo, Junming;Zhong, Jiuchang
背景：微小RNA（miRNA）在癌症发生中发挥重要作用。 miRNA-106a (miR-106a) 在人类中具有致癌活性，并且表达经常发生改变。 miR-106a在胃癌诊断中的临床意义尚不清楚。方法：采用实时逆转录聚合酶链式反应定量55例胃癌组织和17例非肿瘤组织中miR-106a的水平，探讨miR-106a水平与临床病理因素的关系。结果：癌组织中miR-106a的水平 显着高于非肿瘤组织，平均增加1.625倍。 miR-106a水平与肿瘤分期、大小和分化显着相关；淋巴及远处转移；和入侵（P
Background: MicroRNAs (miRNAs) play important roles in carcinogenesis. miRNA-106a (miR-106a) has oncogenic activity in humans, and often has altered expression. The clinical significance of miR-106a in the diagnosis of gastric carcinoma is poorly understood.Methods: The level of miR-106a in 55 gastric carcinoma and 17 non-tumor tissues was quantified by real-time reverse transcriptase-polymerase chain reaction, and the relationship between miR-106a level and clinical and pathological factors was explored.Results: The level of miR-106a in cancer tissues was significantly higher than that in non-tumor tissues, with an average 1.625-fold increase. miR-106a level was significantly associated with tumor stage, size and differentiation; lymphatic and distant metastasis; and invasion (P