The metabolic syndrome and endothelial dysfunction: common highway to type 2 diabetes and CVD.
The metabolic syndrome and endothelial dysfunction: common highway to type 2 diabetes and CVD.
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DOI：
10.1007/s11892-006-0061-4
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发表时间：
2006-08-01
影响因子：
4.2
通讯作者：
Tushuizen, Maarten E
中科院分区：
文献类型：
--
作者：
Diamant, Michaela;Tushuizen, Maarten E
由于全球生活方式的变化，肥胖（2型糖尿病和心血管疾病的主要驱动因素）正在达到流行病的比例。代谢综合征是一种糖尿病前期状态，其特征是同时存在相关的心血管危险因素，包括腹部肥胖、胰岛素抵抗、高血压、血脂异常和葡萄糖耐受不良。内皮功能障碍（艾德）在代谢综合征中很常见，与T2 D和CVD风险增加相关。本文综述了艾德与代谢综合征、2型糖尿病和心血管疾病的相关机制，以及可能改善艾德、降低2型糖尿病和心血管疾病风险的治疗方法。
Due to global lifestyle changes, obesity (the main driver of type 2 diabetes and cardiovascular disease ) is reaching pandemic proportions. The metabolic syndrome, which is regarded as a prediabetic state, is characterized by a concurrence of interrelated cardiovascular risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and glucose intolerance. Endothelial dysfunction (ED) is common in the metabolic syndrome and is associated with increased risk for T2D and CVD. This review focuses on the mechanisms linking ED to the metabolic syndrome, T2D, and CVD, and the possible therapies that may improve ED and reduce T2D and CVD risk.