Effects of repeated annual influenza vaccination on vaccine sero-response in young and elderly adults
Effects of repeated annual influenza vaccination on vaccine sero-response in young and elderly adults
复制标题
DOI：
10.1016/s0264-410x(96)00058-8
复制
发表时间：
1996-10-01
期刊：
影响因子：
5.5
通讯作者：
Osterhaus, ADME
中科院分区：
文献类型：
--
作者：
Beyer, WEP;Palache, AM;Osterhaus, ADME
1986年至1989年期间进行了三项成人队列研究。884名受试者接受了一次或多次流感疫苗免疫，通过血凝抑制休息测定接种前和接种后的抗体滴度。通过对前几年接种和未接种流感疫苗的组之间的每次试验和每种流感（亚）类型进行比较，可以分析 681 名受试者的 1119 次疫苗接种事件。效应大小、比值比和保护率差异被用作效应测量。先前接种疫苗的受试者比未接种疫苗的受试者表现出更高的疫苗接种前抗体。接种后抗体滴度值高的受试者比例相对于先前接种疫苗的平均变化，A-H3N2 疫苗成分为 +9.4%（95% CI：+5.3 至 13.6%），A-H1N1 为 -2.1%（-8.1 至 3.9%，不显着），B 为 -10.6%（-16.5% 至 -4.8%）。在线性回归模型中，疫苗接种前滴度和先前疫苗接种的状态被确定为显着影响疫苗接种后滴度的因素。这些发现是在对文献的简短回顾的背景下讨论的。结论是，以前的疫苗接种状况应始终作为血清学疫苗接种研究的独立因素来考虑。版权所有 (C) 1996 爱思唯尔科学有限公司
Three cohort studies in adults were performed during the periode from 1986 to 1989. Eight hundred and eighty-four subjects were, one or more times, immunized with influenza vaccines, and pre- and post-vaccination antibody titres were determined by hemagglutination inhibition rests. One thousand and one hundred and nineteen vaccination events in 681 subjects could be analysed by a comparison, per trial and per influenza (sub) type, between groups with and without influenza vaccination in previous years. Effect size, odds ratio and protection rate difference, were used as effect measures. Subjects with previous vaccination showed higher pre-vaccination antibody than those without. The average change of the post-vaccination proportion of subjects with high antibody titre value to previous vaccination, was +9.4% (95% CI: +5.3 to 13.6%) for A-H3N2 vaccine components, -2.1% (-8.1 to 3.9%, not significant) for A-H1N1 and -10.6% (-16.5% to -4.8%) for B. In a linear regression model, pre-vaccination titres and the status of previous vaccination were identified as factors significantly influencing post-vaccination titres. These findings are discussed in the context of a short review of the literature. It is concluded that the status of previous vaccination should always be addressed as an independent factor in serological vaccination studies. Copyright (C) 1996 Elsevier Science Ltd.