Class II HLA alleles and hepatitis B virus persistence in African Americans
Class II HLA alleles and hepatitis B virus persistence in African Americans
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DOI：
10.1086/314684
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发表时间：
1999-04-01
影响因子：
6.4
通讯作者：
Thomas, DL
中科院分区：
文献类型：
--
作者：
Thio, CL;Carrington, M;Thomas, DL
持续性B型肝炎病毒（HBV）感染可能是由于病毒和宿主免疫反应的相互作用。鉴于其在抗原呈递中的关键作用，HLA复合体中的等位基因差异可能影响HBV的持久性。在前瞻性随访的非裔美国人队列中，对31名持续HBV感染的受试者和60名清除感染的对照者进行分子I类和II类HLA分型。HBV持续存在与两个II类等位基因DQA 1 *0501显著相关（比值比[OR]，2.6; P=.05）和DQB 1 *0301（OR，3.9; P = .01），由这两个相同的等位基因组成的双位点单倍型（OR，3; P = 0.005）和三位点单倍型，DQA 1 *0501，DQB 1 *0301;和DRB 1 *1102（OR，10.7; P = 0.01）。此外，HBV持续存在与II类等位基因纯合性相关。还注意到几个I类与持久性的关联，但在多重比较校正后没有统计学显著性。这些结果强调了II类介导的免疫应答在HBV感染恢复中的重要性。
Persistence of hepatitis B virus (HBV) infection is likely due to the interplay of the virus and host immune response. Given its critical role in antigen presentation, allelic differences in the HLA complex may affect HBV persistence. In a prospectively followed African American cohort, molecular class I and class II HLA typing was done on 31 subjects with persistent HBV infection:and 60 controls who cleared the infection. HBV persistence was significantly associated with two class II alleles, DQA1*0501 (odds ratio [OR], 2.6; P=.05) and DQB1*0301 (OR, 3.9; P = .01), the two-locus haplotype consisting of these same two alleles (OR, 3; P = .005) and the three-locus haplotype, DQA1*0501, DQB1*0301; and DRB1*1102 (OR, 10.7; P = .01). In addition, HBV persistence was associated with class II allelic homozygosity. Several class I associations with persistence were also noted but were not statistically significant after correction for multiple comparisons. These results underscore the importance of the class II-mediated immune response in recovery from HBV infection.