Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery
Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery
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DOI：
10.3109/21691401.2013.794358
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发表时间：
2014-06-01
影响因子：
5.8
通讯作者：
Shen, Yan
中科院分区：
文献类型：
--
作者：
Chen, Daquan;Yu, Hongyun;Shen, Yan
在这项研究中，我们报道了一种新型的双ph敏感混合胶束，用于制造多核粒子体用于药物递送。以不同的ph敏感聚合物mPEG2000-Hz-CHEMS和mPEG2000-IS （2:1 w/w）制备双ph敏感混合胶束（PMM）。将人参皂苷rh2负载的DPMM与Pluronic F-68混合，在水介质中制备多核核小体。多核核小体的尺寸在100-300 nm左右，G-Rh2包封效率高。G-Rh2- mcn能在较低pH条件下加速释放包封的G-Rh2，具有较低的细胞毒性和较好的抗肿瘤效果。
In this study, we report the novel double pH-sensitive mixed micelles to fabricate multicore niosomes for drug delivery. The double pH-sensitive mixed micelles (PMM) were prepared with different pH-sensitive polymers, mPEG2000-Hz-CHEMS and mPEG2000-IS (2:1 w/w). Ginsenoside Rh2-loaded DPMM was mixed with Pluronic F-68, in the aqueous medium, and multicore niosomes were fabricated. The size of multicore niosomes were around 100-300 nm with a high encapsulation efficiency of G-Rh2. The G-Rh2-MCN could release encapsulated G-Rh2 with an accelerated rate under lower pH conditions with lower cytotoxicity and good antitumor efficacy.