Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy.
Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy.
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DOI：
10.3389/fendo.2020.528146
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发表时间：
2020
影响因子：
5.2
通讯作者：
Lu X
中科院分区：
文献类型：
--
作者：
Chen L;Yang H;Ye E;Lin Z;Peng M;Lin H;Yu L;Cai Z;Lu X
目的：不良的母亲结局和围产期并发症与显性和亚临床母亲甲状腺功能减退症有关。目前尚不清楚这些并发症是否也发生在妊娠期间患有孤立性低甲状腺素血症的妇女中。本研究的目的是评估妊娠期单纯性低甲状腺素血症对母亲和围产儿结局的影响。研究方法：该研究包括2，864名妊娠前三个月（67名患有孤立性低甲状腺素血症的女性，784名甲状腺功能正常的女性）和妊娠中期（70名患有孤立性低甲状腺素血症的女性，1，943名甲状腺功能正常的女性）的数据。在妊娠早期和中期采集孕妇血清样本，检测甲状腺激素浓度。低甲状腺素血症定义为母体促甲状腺激素浓度正常，伴有母体游离甲状腺素浓度低和甲状腺自身抗体阴性。记录了以下产妇结局：妊娠期高血压、妊娠期糖尿病、前置胎盘、胎盘脱垂、产前胎膜破裂和早产。围产期结局，包括胎儿生长受限、胎儿窘迫、低出生体重、宫内胎儿死亡和畸形。比较妊娠早期和妊娠中期单纯性低甲状腺素血症妇女不良妊娠结局和围生期并发症的发生率。结果如下：有没有显着差异的发病率不良孕产妇结局和围产期并发症的患者在第一和第二孕期与孤立性低甲状腺素血症。结论：本研究的结果表明，孤立的甲状腺功能减退症并不增加不良孕产妇结局和围产期并发症的发生率。
Objective: Adverse maternal outcomes and perinatal complications are associated with overt and subclinical maternal hypothyroidism. It is not clear whether these complications also occur in women with isolated hypothyroxinemia during pregnancy. The aim of this study was to evaluate the effects of isolated hypothyroxinemia on maternal and perinatal outcomes during pregnancy. Methods: This study included data from 2,864 pregnant women in the first trimester (67 women with isolated hypothyroxinemia, 784 euthyroid women) and the second trimester (70 women with isolated hypothyroxinemia, 1,943 euthyroid women) of pregnancy. Maternal serum samples were collected in the first and second trimesters to examine thyroid hormone concentration. Hypothyroxinemia was defined as a normal maternal thyroid-stimulating hormone concentration with a low maternal free thyroxine concentration and negative thyroid autoantibodies. The following maternal outcomes were recorded: gestational hypertension, gestational diabetes mellitus, placenta previa, placental abruption, prelabor rupture of membranes, and premature delivery. Perinatal outcomes, including fetal growth restriction, fetal distress, low birth weight, intrauterine fetal death, and malformation. The incidence of adverse pregnancy outcomes and perinatal complications was compared between women in the first trimester and second trimester with isolated hypothyroxinemia. Results: There were no significant differences in the incidence rates of adverse maternal outcomes and perinatal complications between patients in the first and second trimesters with isolated hypothyroxinemia. Conclusion: The results of this study indicate that isolated hypothyroidism does not increase the incidence of adverse maternal outcomes and perinatal complications.
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