Diffusion MRI: apparent diffusion coefficient (ADC) values in the normal brain and a classification of brain disorders based on ADC values
Diffusion MRI: apparent diffusion coefficient (ADC) values in the normal brain and a classification of brain disorders based on ADC values
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DOI：
10.1016/s0895-6111(00)00083-5
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发表时间：
2001-07-01
影响因子：
5.7
通讯作者：
Sener, RN
中科院分区：
文献类型：
--
作者：
Sener, RN
扩散加权成像，取决于水分子的运动，提供有关组织完整性的信息。本文应用平面回波扩散MRI对310例正常脑实质及各种病变的表观扩散系数（ADC）值进行了研究。以正常脑白色物质的ADC值为主要类别，根据其ADC值对脑部疾病进行分类。在正常的白色物质中，ADC范围为0.60-1.05 x 10（-3）mm（2）/s，平均ADC值为0.84 +/- 0.11 x 10（-3）mm（2）/s。可以将脑部疾病以及弥散MRI上的伪影分为5个主要类别：1类，ADC与正常白色物质相似; 2类，ADC低于正常白色物质; 3类，ADC高于正常白色物质; 4类，ADC与CSF相似; 5类，ADC明显低或高。进一步的研究可以提供不同病变的添加以及这些类别的细化。(C)2001爱思唯尔科技有限公司版权所有。
Diffusion-weighted imaging, dependent on motion of water molecules, provides information regarding tissue integrity. Apparent diffusion coefficient (ADC) values in the normal brain parenchyma, and those in a variety of lesions were studied by echo-planar diffusion MRI in 310 cases. Brain disorders were classified based on their ADC values, taking the ADC values of the normal brain white matter as the principal category. In the normal white matter ADC ranges were 0.60-1.05 x 10(-3) mm(2)/s, and the mean ADC value was 0.84 +/- 0.11 x 10(-3) mm(2)/s. It was possible to distribute brain disorders, as well as artefacts on diffusion MRI to five major categories: category 1, ADC similar to normal white matter; category 2, ADC lower than normal white matter; category 3, ADC higher than normal white matter; category 4, ADC similar to CSF; and category 5, markedly low or high ADC. Further studies can provide addition of different lesions as well as refinements of these categories. (C) 2001 Elsevier Science Ltd. All rights reserved.