Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652
Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652
复制标题
Marthiapeptide A 是一种抗感染和细胞毒性聚噻唑环肽，来自深海来源的耐热滨海藻 SCSIO 00652 的 60 L 规模发酵。
DOI：
10.1021/np300554f
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发表时间：
2012-12-01
影响因子：
5.1
通讯作者：
Ju, Jianhua
中科院分区：
文献类型：
--
作者：
Zhou, Xiao;Huang, Hongbo;Ju, Jianhua
从60 L规模培养的中国南海深海来源的耐高温Marinactinospora thermotolerans SCSIO 00652菌株中分离到一个新的含三噻唑-噻唑啉环肽marthiapeptide A（1）。1的平面结构和绝对构型的应用光谱技术，以及通过单晶X-射线衍射和手性相HPLC分析的酸水解产物进行了阐明。Marthiapeptide A（1）对一组革兰氏阳性菌具有抗菌活性，MIC值范围为2.0 - 8.0 μg/mL，对一组人癌细胞系具有较强的细胞毒活性，IC（50）值范围为0.38 - 0.52 μM。
A new sequential tristhiazole-thiazoline-containing cyclic peptide, marthiapeptide A (1), was isolated from a 60 L scale culture of the deep South China Sea-derived strain Marinactinospora thermotolerans SCSIO 00652. The planar structure and absolute configuration of 1 were elucidated by application of spectroscopic techniques, as well as by single-crystal X-ray diffraction and chiral-phase HPLC analysis of the acid hydrolysates. Marthiapeptide A (1) exhibited antibacterial activity against a panel of Gram-positive bacteria, with MIC values ranging from 2.0 to 8.0 μg/mL, and displayed strong cytotoxic activity against a panel of human cancer cell lines with IC(50) values ranging from 0.38 to 0.52 μM.