Synthesis of Menthol Glycinates and Their Potential as Cooling Agents
Synthesis of Menthol Glycinates and Their Potential as Cooling Agents
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DOI：
10.1021/acsomega.9b03624
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发表时间：
2020-02
期刊：
影响因子：
4.1
通讯作者：
D. Klumpp;R. Sobel;S. Kokkinidou;Brian Osei-Badu;Zachary Liveris;Rachel A. Klumpp;Michael R. Stentzel
中科院分区：
文献类型：
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作者：
D. Klumpp;R. Sobel;S. Kokkinidou;Brian Osei-Badu;Zachary Liveris;Rachel A. Klumpp;Michael R. Stentzel
一种新型的潜在凉味剂薄荷醇甘氨酸盐的便捷合成方法已经开发出来。这些化合物是通过两个合成步骤制备的，从溴乙酰溴和 (-)-薄荷醇开始。所得的溴化薄荷醇酯很容易与NH3和1°或2°胺发生取代反应，得到薄荷醇甘氨酸酯。对于大多数制备的化合物，两步合成过程不需要水相萃取。
A convenient method of synthesis has been developed for a new class of potential cooling agents, menthol glycinates. These compounds are prepared in two synthetic steps, starting from bromoacetyl bromide and (−)-menthol. The resulting brominated menthol ester readily undergoes substitution reactions with NH3 and 1° or 2° amines to provide menthol glycinates. For most of the prepared compounds, the two-step synthetic procedure requires no aqueous phase extractions.