CALCIUM DEPENDENCE OF THE INHIBITORY EFFECT OF ANGIOTENSIN ON RENIN SECRETION IN THE ISOLATED PERFUSED KIDNEY OF THE RAT
CALCIUM DEPENDENCE OF THE INHIBITORY EFFECT OF ANGIOTENSIN ON RENIN SECRETION IN THE ISOLATED PERFUSED KIDNEY OF THE RAT
复制标题
血管紧张素对大鼠离体灌流肾肾素分泌抑制作用的钙依赖性
DOI：
10.1111/j.1476-5381.1974.tb09599.x
复制
发表时间：
1974
影响因子：
7.3
通讯作者：
W. Peart
中科院分区：
文献类型：
--
作者：
R. Dongen;W. Peart
研究了钙对生物活性血管紧张素对肾素分泌的抑制作用。在钙（3.7 mm）存在的情况下，asp(NH2) '‐血管紧张素II抑制了基础和异丙肾上腺素刺激的肾素分泌。肾灌注压因血管紧张素的输注而升高，在加入异丙肾上腺素后恢复到控制水平。3当钙浓度降至0.32 mm时，血管紧张素产生的血管收缩被消除，但对肾素分泌的抑制作用仍然明显。在缺乏钙的情况下，血管紧张素不再抑制基础肾素分泌，添加异丙肾上腺素后肾素分泌迅速增加。在无钙灌注中观察到较高的基础肾素水平，表明存在肾内钙依赖机制调节基础肾素分泌。这些观察结果表明，生物活性血管紧张素对基础和异丙肾上腺素刺激的肾素分泌的抑制作用，在功能上与依赖钙的收缩反应有关。肾素产生细胞是改良的平滑肌细胞，这一认识支持了这种关联
1 The effect of calcium on the inhibition of renin secretion by biologically active angiotensin was investigated in the isolated rat kidney perfused with Krebs‐Ringer saline. 2 In the presence of calcium (3.7 mm), asp(NH2)′‐angiotensin II suppressed both basal and isoprenaline‐stimulated renin secretion. Renal perfusion pressure, which was increased by the infusion of angiotensin, returned to control levels when isoprenaline was added. 3 When the calcium concentration was reduced to 0.32 mm, the vasoconstriction produced by angiotensin was abolished although the inhibitory effect on renin secretion was still evident. 4 In the absence of calcium, angiotensin no longer suppressed basal renin secretion and a prompt increase in renin secretion occurred when isoprenaline was added. 5 The higher basal renin levels which were observed in calcium‐free perfusions, suggest the existence of an intrarenal calcium‐dependent mechanism that regulates basal renin secretion. 6 These observations indicate that the inhibitory effect of biologically active angiotensin, on basal and isoprenaline‐stimulated renin secretion, is functionally related to the contractor response by its dependence on calcium. The recognition that the renin‐producing cells are modified smooth muscle cells supports this association