Crystalline Calcium Alendronate Obtained by Octacalcium Phosphate Digestion: A New Chance for Local Treatment of Bone Loss Diseases?
Crystalline Calcium Alendronate Obtained by Octacalcium Phosphate Digestion: A New Chance for Local Treatment of Bone Loss Diseases?
复制标题
DOI：
10.1002/adma.201301129
复制
发表时间：
2013-09-06
影响因子：
29.4
通讯作者：
Bigi, Adriana
中科院分区：
文献类型：
--
作者：
Boanini, Elisa;Torricelli, Paola;Bigi, Adriana
磷酸八钙（OCP）与阿仑膦酸钠（AL）溶液的相互作用导致OCP完全消化：钙离子被双膦酸盐吸收，产生定量的结晶阿仑膦酸钠钙一水合物沉淀。该化合物单独使用以及与OCP联合使用时，可改善成骨细胞分化，抑制破骨细胞增殖和活性。
Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP.