Acetaldehyde-induced Changes in the Monoamine and Amino Acid Extracellular Microdialysate Content of the Nucleus Accumbens
Acetaldehyde-induced Changes in the Monoamine and Amino Acid Extracellular Microdialysate Content of the Nucleus Accumbens
复制标题
乙醛诱导的伏核细胞外微透析液单胺和氨基酸含量的变化
DOI：
10.1016/s0028-3908(97)00007-5
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发表时间：
1997
影响因子：
4.7
通讯作者：
P. Witte
中科院分区：
文献类型：
--
作者：
R. Ward;C. Colantuoni;A. Dahchour;E. Quertemont;P. Witte
采用微透析技术研究了急性腹腔注射乙醛（20 mg/kg或100 mg/kg）对伏隔核（NA）中氨基酸和单胺微透析液含量的影响。乙酰胆碱乙醛（ACH）在注射后10 min可检测到50-130 μmol/g脑组织水平，引起细胞外微透析多巴胺含量显著降低，并持续120 min。高香草酸（HVA）在较低剂量的乙酰胆碱（ACH）作用下显著降低，而二氢苯乙酸（DOPAC）在研究期间随两种剂量的乙酰胆碱（ACH）作用均无显著变化。两种剂量的乙醛后血清素水平均显著下降，其主要代谢物羟吲哚乙酸（5-HIAA）随着乙醛剂量的增加而显著增加。在两种剂量的乙醛后，牛磺酸仅在头20分钟内显著增加，尽管兴奋性氨基酸（谷氨酸和天冬氨酸）和抑制性氨基酸（氨基丁酸）均未显示任何显著变化。乙醛明显引起NA单胺含量的显著扰动，这种变化与乙醇处理后单胺含量的变化相反，这可能表明负强化效应。©1997 Elsevier Science Ltd.出版版权所有。
The effect of an acute intraperitoneal (i.p.) injection of acetaldehyde, 20 mg/kg or 100 mg/kg, on the microdialysate content of both amino acids and monoamines was studied in the nucleus accumbens (NA) by a microdialysis technique. Acetaldehyde, ACH, which was detectable at levels of 50–130 μmol/g brain tissue 10 min after injection, evoked a significant decrease in the extracellular microdialysis dopamine content, which was sustained for the period of the study, i.e. 120 min. Homovanillic acid, HVA, decreased significantly when the lower dose of ACH was administered while dihydrophenylacetic acid, DOPAC, showed no significant change with either dose of ACH during the period of the study. Serotonin levels decreased significantly after both doses of acetaldehyde, with significant increases of its major metabolite, hydroxyindolacetic acid, 5-HIAA, with the higher acetaldehyde dose. Taurine increased significantly, only during the first twenty minutes, after both doses of acetaldehyde, although neither of the excitatory amino acids assayed, glutamate and aspartate, nor the inhibitory amino acid, GABA, showed any significant changes. Acetaldehyde clearly evokes significant perturbation in the monoamine content of the NA, such changes being the converse to those reported for monoamines after ethanol administration, which might indicate a negative reinforcement effect. © 1997 Published by Elsevier Science Ltd. All rights reserved.
DOI：
10.1016/0741-8329(88)90068-7
发表时间：
1988
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Khatib,SA;Murphy,JM;McBride,WJ
通讯作者：
McBride,WJ
酒精刺激伏隔核中多巴胺和血清素的释放。
DOI：
10.1016/0741-8329(92)90004-t
发表时间：
1992
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Yoshimoto,K;McBride,WJ;Lumeng,L;Li,TK
通讯作者：
Li,TK
影响因子：
2.3
作者：
BROWN, RA;CARPENTIER, RG
通讯作者：
CARPENTIER, RG