Body weight and weight gain during adult life in men in relation to coronary heart disease and mortality - A prospective population study
Body weight and weight gain during adult life in men in relation to coronary heart disease and mortality - A prospective population study
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DOI：
10.1053/euhj.1998.1235
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发表时间：
1999-02-01
影响因子：
39.3
通讯作者：
Wilhelmsen, L
中科院分区：
文献类型：
--
作者：
Rosengren, A;Wedel, H;Wilhelmsen, L
Aims To assess the risk of death from coronary disease，and all causes associated with body mass index and weight gain from age 20 to middle age.Methods and Results在这项研究中，6874名男性年龄在47至55岁的基线和免费的历史心肌梗死被随访了冠状动脉疾病和所有原因的死亡率，平均随访19.7年，非致死性心肌梗死11.8年。高体重指数预测冠心病死亡，但仅在高于27.5m.kg（-2）的水平。体重稳定的男性（定义为从20岁起变化+/- 4%）冠心病死亡率最低，非致命性心肌梗死的风险最低。冠状动脉死亡的相对风险随着体重增加而增加，与体重保持稳定的男性相比，体重增加4%至10%的男性的相对风险为1.57（1.14-2.15）（经年龄，体力活动和吸烟调整后），体重增加超过35%的男性为2.76（1.97-3.85）（趋势P为0.0001）。在进一步校正血清胆固醇、收缩压和糖尿病后，相对风险降低，但在所有体重增加组中仍显着升高（趋势P <0.004）。关于非致命性心肌梗死的数据在前11.8年可用，显示相对危险度为3.35（2.05-5.47）在调整年龄、体力活动和吸烟后，体重增加超过35%的男性。与冠状动脉死亡和非致命性心肌梗死的风险增加密切相关。
Aims To assess the risk of death from coronary disease, and all causes associated with body mass index and weight gain from age 20 to middle age.Methods and Results In this study, 6874 men aged 47 to 55 years at baseline and free of a history of myocardial infarction were followed with respect to mortality from coronary disease and from all causes over an average follow-up of 19.7 years, and with respect to non-fatal myocardial infarction for 11.8 years. High body mass index predicted death from coronary disease, but only at levels above 27.5m.kg(-2). Men with stable weight (defined as +/- 4% change from age 20) had the lowest death rate from coronary disease and the lowest risk of non-fatal myocardial infarction. Relative risk of coronary death increased with increasing weight gain, from 1.57 (1.14-2.15) (after adjustment for age, physical activity, and smoking) in the group who gained 4 to 10%, to 2.76 (1.97-3.85) in men with a weight gain of more than 35% (P for trend 0.0001), compared to men who remained stable. After further adjustment for serum cholesterol, systolic blood pressure, and diabetes, relative risks were reduced but still significantly elevated in all weight gain groups (P for trend 0.004). Data concerning non-fatal myocardial infarction were available for the first 11.8 years and showed a relative risk of 3.35 (2.05-5.47) after adjustment for age, physical activity, and smoking in men with a weight gain of more than 35%.Conclusion Weight gain from age 20, even a very moderate increase, is strongly associated with an increased risk of coronary death and non-fatal myocardial infarction.