PLASMA CYTOKINE LEVELS IN NECROTIZING ENTEROCOLITIS
PLASMA CYTOKINE LEVELS IN NECROTIZING ENTEROCOLITIS
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DOI：
10.1111/j.1651-2227.1994.tb13235.x
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发表时间：
1994-04-01
期刊：
影响因子：
3.8
通讯作者：
HOLMES, SJK
中科院分区：
文献类型：
--
作者：
MORECROFT, J;SPITZ, L;HOLMES, SJK
血浆肿瘤坏死因子（TNF）和白细胞介素-6（IL-6）的浓度测定从24例婴儿坏死性小肠结肠炎（NEC）从诊断0和306小时之间的样本中采用ELISA法。在71%的样本中检测到TNF（> 10 pg/ml），平均值为48 pg/ml（95% CI 42至55 pg/ml），并且不随诊断时间或疾病严重程度而变化。IL-6在前48小时内升高，II期（平均127 pg/ml，95% CI 10至329 pg/ml）和III期（平均3127 pg/ml，95% CI 1809至4445 pg/ml，p = 0.001）之间存在显著差异。术后血浆IL-6浓度下降至II期相似水平（平均150 pg/ml，95% CI 37 - 283 pg/ ml，p = 0.79）。我们的结论是，血浆中IL-6的浓度，而不是肿瘤坏死因子反映了坏死性小肠结肠炎的临床严重程度，这些细胞因子的相对水平有重要的意义，使用抗细胞因子治疗NEC。
Plasma concentrations of tumour necrosis factor (TNF) and interleukin-6 (IL-6) were measured by ELISA in samples taken from 24 infants with necrotizing enterocolitis (NEC) between 0 and 306 h from diagnosis. TNF was detected (> 10 pg/ml) in 71% samples with a mean of 48 pg/ml (95% CI 42 to 55 pg/ml) and did not vary with either time from diagnosis or severity of disease. IL-6 was raised during the first 48 h with a significant difference between stage II (mean 127 pg/ml, 95% CI 10 to 329 pg/ml) and stage III (mean 3127 pg/ml, 95% CI 1809 to 4445 pg/ml, p = 0.001). Postoperative plasma IL-6 concentration fell to similar levels seen in stage II (mean 150 pg/ml, 95% CI 37 to 283 pg/ ml, p = 0.79). We conclude that plasma concentration of IL-6 rather than TNF reflects the clinical severity of necrotizing enterocolitis and that the relative level of these cytokines has important implications for the use of anti-cytokine therapy in NEC.