Central alpha-adrenoceptors during the development of hypertension in rats on high and low salt intake.
Central alpha-adrenoceptors during the development of hypertension in rats on high and low salt intake.
复制标题
高盐摄入和低盐摄入大鼠高血压发展过程中的中枢α-肾上腺素受体。
DOI：
10.1097/00004872-198612000-00006
复制
发表时间：
1986
影响因子：
4.9
通讯作者：
Gavras,H
中科院分区：
文献类型：
--
作者：
Bresnahan,MR;Gavras,I;Hatinoglou,S;Muller,RE;Gavras,H
Our purpose was to investigate the binding characteristics of central a-adrenoceptors during the early stages of the development of hypertension in rats on high and low salt (NaCI) intake. We measured ar ([3H] prazosin) and a2-([3H] rauwolscine) binding in membranes of the hypothalamus' and*\medulla oblongata of six groups of young Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and subtotally nephrectomized WKY (SN) rats with mean arterial blood pressure (MAP) ranging from normotensive to hypertensive levels-after 1 week of salt restriction or loading. In the hypothalamus the SN-high salt rats and both SHR groups had elevated^-number but there was no change in a2-number. Moreover, MAP was positively correlated with mean hypothalamic arnumber in the six groups. In the medulla oblongata^-number was unaffected. However, high salt diet influenced medullary a2-binding in the opposite manner in WKY rats versus SN rats and SHR. In these latter groups the affinity was increased and the number decreased in response to high salt intake. Furthermore, a positive correlation between MAP and mean ai: a2 ratio existed in both the hypothalamus and the medulla of the six groups.
