Copper complex catalyzed asymmetric monosulfonylation of meso-vic-diols
Copper complex catalyzed asymmetric monosulfonylation of meso-vic-diols
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DOI：
10.1016/j.tetlet.2007.08.104
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发表时间：
2007-10-22
影响因子：
1.8
通讯作者：
Matsumura, Yoshihiro
中科院分区：
文献类型：
--
作者：
Demizu, Yosuke;Matsumoto, Kazuya;Matsumura, Yoshihiro
在三氟甲磺酸铜（II）和（R，R）-Ph-BOX催化剂的存在下，通过甲苯磺酰化反应进行了内消旋-vic-二醇的对称去对称化。该方法成功地应用于环状和非环状meso-vic-二醇的不对称去对称化，对映选择性高达> 99%ee。（C）2007 Elsevier Ltd.保留所有权利。
A symmetric desymmetrization of meso-vic-diols was performed by tosylation in the presence of copper(II) triflate and (R,R)-Ph-BOX as a catalyst. The method was successfully applied to asymmetric desymmetrization of cyclic and acyclic meso-vic-diols in high enantioselectivity with up to >99% ee. (C) 2007 Elsevier Ltd. All rights reserved.