Isolation and structure elucidation of a new antifungal and antibacterial antibiotic produced by Streptomyces sp 201
Isolation and structure elucidation of a new antifungal and antibacterial antibiotic produced by Streptomyces sp 201
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DOI：
10.1271/bbb.65.1856
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发表时间：
2001-08-01
影响因子：
1.6
通讯作者：
Bora, TC
中科院分区：
文献类型：
--
作者：
Bordoloi, GN;Kumari, B;Bora, TC
从链霉菌201的培养滤液中分离得到一种抗菌抗真菌抗生素，经核磁共振波谱分析确定其结构为异烟酸2-甲基庚酯。该化合物对枯草芽孢杆菌、志贺氏菌、克雷伯氏菌属，E.大肠杆菌、奇异变形杆菌（Proteus mirabilis）和病原真菌串珠镰刀菌（Fusarium moniliforme）、串珠镰刀菌（F. semitectum、尖孢镰刀菌（F：oxysporum）、立枯丝核菌（E solani）和立枯丝核菌（Rhizoctonia solani）。
An antibacterial and antifungal antibiotic was isolated from the culture filtrate of Streptomyces sp. 201, and its structure was determined as 2-methyl-heptyl isonicotinate by extensive use of NMR spectroscopy. The compound exhibited marked antimicrobial activity against Bacillus subtilis, Shigella sp., Klebsiella-sp., E. coli, Proteus mirabilis, and the pathogenic fungi, Fusarium moniliforme, F. semitectum, F: oxysporum, E solani and Rhizoctonia solani.