Food Restriction Engages Prefrontal Corticostriatal Cells and Local Microcircuitry to Drive the Decision to Run versus Conserve Energy.
Food Restriction Engages Prefrontal Corticostriatal Cells and Local Microcircuitry to Drive the Decision to Run versus Conserve Energy.
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食物限制会影响前额叶皮质纹状体细胞和局部微电路，以推动跑步与节约能量的决定。
DOI：
10.1093/cercor/bhaa394
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Aoki,Chiye
中科院分区：
文献类型：
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作者：
Santiago,AdrienneN;Makowicz,EmilyA;Du,Muzi;Aoki,Chiye
食物限制（FR）会引发跑步，这可能会在食物短缺的时候促进适应性觅食，但如果能量消耗超过热量可用性，则可能会致命。在这里，我们证明，无论是一般内侧前额叶皮层（mPFC）锥体细胞群，或亚群投射到背侧纹状体（DS）驱动器运行特定的时间在有限的食物供应，而不是duringad libitumfood可用性。相反，通常抑制mPFC锥体细胞或靶向mPFC至DS细胞，会特别在FR期间而不是在自由进食期间减少车轮运行。mPFC第5层的死后c-Fos分析和电子显微镜检查显示，与邻近的非DS投射锥体细胞相比，mPFC至DS细胞具有以下显著特征：1）GABA能活性的募集更大，2）轴体GABA能神经支配更少。总之，这些属性的位置mPFC到DS的锥体细胞的子集占主导地位的mPFC兴奋性流出，特别是在FR，揭示了一个特定的和因果关系的作用mPFC到DS控制的决定运行在食物短缺。GABA能活性的个体差异与跑步反应相关，以进一步支持这一解释。FR增强PFC到DS的活动可能会影响神经回路，无论是在使用FR激励动物行为的研究中，还是在以FR为标志的人类条件下。
Food restriction (FR) evokes running, which may promote adaptive foraging in times of food scarcity, but can become lethal if energy expenditure exceeds caloric availability. Here, we demonstrate that chemogenetic activation of either the general medial prefrontal cortex (mPFC) pyramidal cell population, or the subpopulation projecting to dorsal striatum (DS) drives running specifically during hours preceding limited food availability, and not duringad libitumfood availability. Conversely, suppression of mPFC pyramidal cells generally, or targeting mPFC-to-DS cells, reduced wheel running specifically during FR and not duringad libitumfood access. Post mortem c-Fos analysis and electron microscopy of mPFC layer 5 revealed distinguishing characteristics of mPFC-to-DS cells, when compared to neighboring non–DS-projecting pyramidal cells: 1) greater recruitment of GABAergic activity and 2) less axo-somatic GABAergic innervation. Together, these attributes position the mPFC-to-DS subset of pyramidal cells to dominate mPFC excitatory outflow, particularly during FR, revealing a specific and causal role for mPFC-to-DS control of the decision to run during food scarcity. Individual differences in GABAergic activity correlate with running response to further support this interpretation. FR enhancement of PFC-to-DS activity may influence neural circuits both in studies using FR to motivate animal behavior and in human conditions hallmarked by FR.