Rattle‐Type Fe3O4@CuS Developed to Conduct Magnetically Guided Photoinduced Hyperthermia at First and Second NIR Biological Windows
Rattle‐Type Fe3O4@CuS Developed to Conduct Magnetically Guided Photoinduced Hyperthermia at First and Second NIR Biological Windows
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DOI：
10.1002/adfm.201503015
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发表时间：
2015-11
影响因子：
19
通讯作者：
Z. Wu;W. Li;Cheng-Hung Luo;C. Su;C. Yeh
中科院分区：
文献类型：
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作者：
Z. Wu;W. Li;Cheng-Hung Luo;C. Su;C. Yeh
创建了第二个近红外（NIR）窗口中的治疗载体，通过磁体和近红外激光的操纵，具有磁靶、磁共振成像（MRI）诊断和光热治疗功能。开发了一种以拨浪鼓型 Fe3O4@CuS 纳米颗粒形式存在的蓝铜基 CuS，可分别在第一和第二近红外窗口的 808 和 1064 nm 处进行光致高温。 Fe3O4@CuS 纳米颗粒在 700 至 1300 nm 范围内表现出广泛的近红外吸收。体外光热结果表明，使用808 nm照射获得的激光强度需要将其强度增加两倍才能对细胞产生与使用1064 nm照射获得的相同的损伤。由于 Fe3O4 具有良好的磁性，因此可以进行磁引导光热肿瘤消融来评估两种激光照射。根据固定激光强度和照射光斑下的结果，照射1064 nm的肿瘤完全切除，没有复发迹象。另一方面，808 nm 照射可有效抑制生长，长达 30 天几乎保持不变，但肿瘤并未完全消除。此外，还进行 MRI 来监测磁吸引力后肿瘤中拨浪鼓型 Fe3O4@CuS 的定位。
A therapeutic carrier in the second near‐infrared (NIR) window is created that features magnetic target, magnetic resonance imaging (MRI) diagnosis, and photothermal therapy functions through the manipulation of a magnet and NIR laser. A covellite‐based CuS in the form of rattle‐type Fe3O4@CuS nanoparticles is developed to conduct photoinduced hyperthermia at 808 and 1064 nm of the first and second NIR windows, respectively. The Fe3O4@CuS nanoparticles exhibit broad NIR absorption from 700 to 1300 nm. The in vitro photothermal results show that the laser intensity obtained using 808 nm irradiation required a twofold increase in its magnitude to achieve the same damage in cells as that obtained using 1064 nm irradiation. Because of the favorable magnetic property of Fe3O4, magnetically guided photothermal tumor ablation is performed for assessing both laser exposures. According to the results under the fixed laser intensity and irradiation spot, exposure to 1064 nm completely removed tumors showing no signs of relapse. On the other hand, 808 nm irradiation leads to effective inhibition of growth that remained nearly unchanged for up to 30 d, but the tumors are not completely eliminated. In addition, MRI is performed to monitor rattle‐type Fe3O4@CuS localization in the tumor following magnetic attraction.