DEVELOPMENTAL-CHANGES OF CALPAIN AND CALPASTATIN IN RABBIT BRAIN
DEVELOPMENTAL-CHANGES OF CALPAIN AND CALPASTATIN IN RABBIT BRAIN
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DOI：
10.1007/bf00965622
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发表时间：
1989-11-01
影响因子：
4.4
通讯作者：
KARLSSON, JO
中科院分区：
文献类型：
--
作者：
BLOMGREN, K;KARLSSON, JO
钙激活的蛋白水解活性的一个主要部分，在从兔脑的可溶性部分可能是由于中性巯基蛋白酶钙蛋白酶I和II的活性。钙蛋白酶的活性超过了内源性抑制剂，钙蛋白酶抑制素，在所有的发育阶段研究。钙蛋白酶水平从出生前开始迅速升高，在出生后10-20天达到高峰。从这一时期开始，钙蛋白酶的水平缓慢下降，达到成人水平。钙蛋白酶抑制蛋白水平从产前阶段到老年稳步上升。
A major part of the Ca-activated proteolytic activity in the soluble fraction from rabbit brain could be due to the activity of the neutral thiol-proteases calpain I and II. The activity of calpains exceeded that of the endogenous inhibitor, calpastatin, at all developmental stages studied. The level of calpains increased rapidly from the prenatal stage to reach a peak 10-20 days postnatally. From this period the level of calpains decreased slowly to reach the adult levels. The level of calpastatin increased steadily from the prenatal stage to old age.