Epigenetics of cancer-associated muscle catabolism
Epigenetics of cancer-associated muscle catabolism
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DOI：
10.2217/epi-2017-0058
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发表时间：
2017-10-01
期刊：
影响因子：
3.8
通讯作者：
Fernandez-Zapico, Martin E.
中科院分区：
文献类型：
--
作者：
Carr, Ryan M.;Enriquez-Hesles, Elisa;Fernandez-Zapico, Martin E.
癌症患者通常受到恶病质的影响，这是一种涉及肌肉和脂肪的消耗过程。具体来说，肌肉间室的丧失与预后不良和治疗反应不佳有关。营养支持在治疗这一过程中是无效的，导致对控制肌肉分解代谢的潜在分子过程的调查。在这篇评论中，我们讨论了癌症相关肌肉代谢的分子机制和肌肉萎缩表型的表观遗传过程。最后，我们强调了表观基因组如何作为逆转癌症相关肌肉分解代谢的有希望的治疗靶点。
Cancer patients are commonly affected by cachexia, a wasting process involving muscle and fat. Specifically, loss of the muscle compartment has been associated with poor prognosis and suboptimal response to therapy. Nutritional support has been ineffective in treating this process leading to investigations into the underlying molecular processes governing muscle catabolism. In this commentary, we discuss the molecular mechanisms of cancer-associated muscle metabolism and the epigenetic processes responsible for the muscle wasting phenotype. Ultimately, we highlight how the epigenome may serve as a promising therapeutic target in reversing cancer-associated muscle catabolism.