Is metronidazole carcinogenic?
Is metronidazole carcinogenic?
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DOI：
10.1016/s1383-5742(02)00007-8
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发表时间：
2002-06-01
影响因子：
5.3
通讯作者：
Ostrosky-Wegman, P
中科院分区：
文献类型：
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作者：
Bendesky, A;Menéndez, D;Ostrosky-Wegman, P
甲硝唑（MTZ，1-[2-羟乙基]-2-甲基-5-硝基咪唑）是一种抗寄生虫和抗菌化合物，是世界上使用最多的药物之一。由于以下事实，MTZ对人类具有潜在致癌性：它是细菌系统中已证实的诱变剂，对人类细胞具有遗传毒性，并且对动物具有致癌性。然而，由于流行病学证据不足，它不被认为是人类癌症的风险因素。正如本文所讨论的，现有的人群研究存在缺陷，因为它们没有包括足够的样本量，随访时间不够长，个体对药物的敏感性可能是一个混杂因素，由于该药的使用越来越多，需要更多和改进的研究来阐明其遗传毒性机制及其致癌潜力。(C)2002 Elsevier Science B. V.保留所有权利。
Metronidazole (MTZ, 1-[2-hydroxyethyl]-2-methyl-5-nitroimidazole), an antiparasitic and antibacterial compound, is one of the world's most used drugs. MTZ is potentially carcinogenic to humans due to the following facts: it is a proven mutagen in bacterial systems, it is genotoxic to human cells and also, it is carcinogenic to animals. However, due to inadequate epidemiological evidence, it is not considered as a risk factor for cancer in humans. As it will be discussed here, the existing population studies are deficient since they have not included sufficient sample size, the follow-up time has not been long enough, and the individual sensitivity to the drug might have been acting as a confounding factor, Due to the increasing use of this drug, more and improved studies are needed to elucidate its mechanism of genotoxicity and its carcinogenic potential. (C) 2002 Elsevier Science B.V. All rights reserved.