Test-retest reliability of the unified Parkinson's disease rating scale in patients with early Parkinson's disease: Results from a multicenter clinical trial
Test-retest reliability of the unified Parkinson's disease rating scale in patients with early Parkinson's disease: Results from a multicenter clinical trial
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DOI：
10.1002/mds.10011
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发表时间：
2002-07-01
影响因子：
8.6
通讯作者：
Shoulson, I
中科院分区：
文献类型：
--
作者：
Siderowf, A;McDermott, M;Shoulson, I
我们的目标是评估统一帕金森氏病评定量表(UPDRS)的重测信度。UPDRS是临床研究和实践中最广泛使用的测量帕金森症状严重程度的工具。该量表的效度和评分者间的信度已经被研究过了。我们检验了UPDRS和派生分量表的重测(内部)信度。400名早期帕金森病(PD)患者参加了一项多中心临床试验，在接受治疗之前，他们在两个不同的场合(筛查和基线访问)使用UPDRS进行了评估。每个中心的同一名神经科医生在两次检查中对受试者进行评分，平均相隔14.6+/-7.6天(范围3-36天)。重测信度的评估使用组内相关系数(ICC)的UPDRS总分，心理，日常生活能力和运动分量表，以及其他派生的子量表分数。计算了各个UPDRS项目的加权kappa统计量。UPDRS评分的ICC为：总分0.92分，心理分0.74分，日常生活能力0.85分，运动分0.90分。衍生症状量表的ICCS范围为0.69-0.88。具体条目的信度普遍低于简明量表。在测试间隔在14天内的患者中，可靠性略好一些。根据传统标准，UPDRS评分在这个由学术运动障碍专家评定的早期帕金森病患者样本中被发现具有极好的重测可靠性。这一发现与之前关于石油分级器可靠性的报道一致。(C)2002年行动失调社。
Our objective was to assess the test-retest reliability of the Unified Parkinson's Disease Rating Scale (UPDRS). The UPDRS is the most widely used instrument for measuring severity of parkinsonian symptoms in clinical research and in practice. The validity and inter-rater reliability of this scale have been previously studied. We examined the test-retest (intrarater) reliability of the UPDRS and derived subscales. Four hundred patients with early-stage Parkinson's disease (PD) who were participating in a multicenter clinical trial were evaluated using the UPDRS on two separate occasions (screening and baseline visits) prior to receiving treatment. The same neurologist at each center rated the subjects at both examinations that were, on average, 14.6 +/- 7.6 days apart (range 3-36 days). Test-retest reliability was estimated using the intraclass correlation coefficient (ICC) for the total UPDRS score, the mental, ADL, and motor subscale scores, and other derived subscale scores. Weighted kappa statistics were calculated for individual UPDRS items. The ICCs for the UPDRS scores were as follows: total score, 0.92; mental, 0.74; ADL, 0.85; motor, 0.90. ICCs for derived symptom-based scales ranged from 0.69-0.88. Reliability of specific items was generally lower than for summary scales. Reliability was slightly better in patients for whom the testing interval was within 14 days. Based on conventional standards, the UPDRS scores were found to have excellent test-retest reliability in this sample of patients with early PD rated by academic movement disorder specialists. The findings are in agreement with previous reports Oil interrater reliability. (C) 2002 Movement Disorder Society.