Synthesis and antimalarial activity in vitro of new heterobimetallic complexes: Rh and Au derivatives of chloroquine and a series of ferrocenyl-4-amino-7-chloroquinolines
Synthesis and antimalarial activity in vitro of new heterobimetallic complexes: Rh and Au derivatives of chloroquine and a series of ferrocenyl-4-amino-7-chloroquinolines
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DOI：
10.1016/j.jorganchem.2003.07.026
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发表时间：
2003-12-15
影响因子：
2.3
通讯作者：
Smith, PJ
中科院分区：
文献类型：
--
作者：
Blackie, MAL;Beagley, P;Smith, PJ
本文研究了氯喹及其二茂铁衍生物与Au（PPh_3）NO_3、Au（C_6F_5）（tht）和[Rh（COD）Cl]（2）的反应。所得到的产品已通过一系列技术，包括NMR，质谱，元素分析，IR和循环伏安法进行了表征。数据表明，产物是喹啉氮与Au或Rh配位的杂环配合物。报告了对恶性疟原虫的体外研究。(C)2003 Elsevier B.V.保留所有权利。
The reaction of chloroquine and several ferrocenyl derivatives of chloroquine with Au(PPh3)NO3, Au(C6F5)(tht) and [Rh(COD)Cl](2) have been investigated. The resulting products have been characterised by a range of techniques including NMR, mass spectrometry, elemental analysis, IR and cyclic voltammetry. The data suggests that the products are heterobimetallic complexes where the quinoline nitrogen coordinates to the Au or Rh. In vitro studies against Plasmodium falciparum are reported. (C) 2003 Elsevier B.V. All rights reserved.