Acute effects of transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women
Acute effects of transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women
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DOI：
10.1016/s0015-0282(97)81857-2
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发表时间：
1997-01-01
影响因子：
6.7
通讯作者：
Schonauer, LM
中科院分区：
文献类型：
--
作者：
Cicinelli, E;Ignarro, LJ;Schonauer, LM
目的：研究经皮给予E2对绝经后妇女血浆一氧化氮（NO）水平的急性影响。设计：随机、安慰剂对照试验。设置：学术研究环境中的正常人类志愿者。患者：20名健康绝经后妇女。干预：经皮给予100 μ g/d E2或安慰剂。主要结果测量：在给药前和给药后24小时测定血浆NO稳定氧化产物浓度和血清E（2）浓度。在E（2）治疗组中，贴敷贴剂后24小时NO代谢物的平均浓度（37.31 ± 7.62 μ mol/L）显著高于基线（21.04 ± 5.71 μ mol/L）和对照组（23.50 ± 4.03 μ mol/L）。E2给药后24小时NO代谢产物的平均增加百分比与E2绝对浓度之间的相关性具有统计学显著性。结论：经皮给药E2可增加健康绝经后妇女血浆NO水平，这支持了一种与NO相关的机制可能有助于绝经后雌激素的心血管保护作用的假说。
Objective: To investigate the acute effects of transdermal E(2) administration on nitric oxide (NO) plasma levels in postmenopausal women.Design: Randomized, placebo-controlled trial.Setting: Normal human volunteers in an academic research environment.Patient(s): Twenty healthy postmenopausal women.Intervention(s): Transdermal administration of 100 mu g/d E(2) Or placebo.Main Outcome Measure(s): Plasma concentrations of NO stable oxidation products and serum concentrations of E(2) were assessed before and 24 hours after the administration.Result(s): In the group treated with E(2) mean concentration of NO metabolites 24 hours after patch application (37.31 +/- 7.62 mu mol/L) resulted significantly higher than baseline (21.04 +/- 5.71 mu mol/L) and the control group (23.50 +/- 4.03 mu mol/L). The correlation between the mean percent increase in NO metabolites and absolute E(2) concentrations 24 hours after the E(2) administration was statistically significant.Conclusion(s): Transdermal administration of E(2) to healthy postmenopausal women increases the plasma levels of NO and this supports the hypothesis that a NO-related mechanism may contribute to the cardiovascular protective effect of estrogens in postmenopause.