Early Initiation Rather Than Prolonged Duration of Antiretroviral Therapy in HIV Infection Contributes to the Normalization of CD8 T-Cell Counts
Early Initiation Rather Than Prolonged Duration of Antiretroviral Therapy in HIV Infection Contributes to the Normalization of CD8 T-Cell Counts
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DOI：
10.1093/cid/civ809
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发表时间：
2016-01-15
影响因子：
11.8
通讯作者：
Routy, Jean-Pierre
中科院分区：
文献类型：
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作者：
Cao, Wei;Mehraj, Vikram;Routy, Jean-Pierre
背景。即使在长期抗逆转录病毒治疗（ART）后，人类免疫缺陷病毒（HIV）感染的CD8 t细胞计数仍然升高，这与非艾滋病相关事件的风险增加有关。我们评估了早期抗逆转录病毒治疗与慢性HIV感染对CD8细胞计数随时间变化轨迹的影响。在原发性HIV感染（PHI）期间登记的280人中，251人随访了24个月；84人在感染6个月前开始接受抗逆转录病毒治疗（eART）， 49人在6至24个月间开始接受治疗，118人仍未接受治疗。在每次研究访问时评估血浆HIV病毒载量（VL）、CD4和CD8细胞计数。我们还检测了182名年龄匹配的hiv感染者的CD8计数，这些感染者在慢性感染期间开始抗逆转录病毒治疗，血浆VL维持了50 = 5年。在PHI基线，较高的CD8细胞计数与近期感染相关（P = 0.02），较高的CD4细胞计数（P = 0.02）
Background. CD8 T-cell counts remain elevated in human immunodeficiency virus (HIV) infection even after long-term antiretroviral therapy (ART), which is associated with an increased risk of non-AIDS-related events. We assessed the impact of ART initiation in early versus chronic HIV infection on trajectories of CD8 cell counts over time.Methods. Of 280 individuals enrolled during primary HIV infection (PHI), 251 were followed up for 24 months; 84 started ART before 6 months of infection (eART), 49 started between 6 and 24 months, and 118 remained untreated. Plasma HIV viral load (VL), CD4 and CD8 cell counts were assessed at each study visit. CD8 counts were also examined in 182 age-matched HIV-infected individuals who started ART during chronic infection and maintained undetectable plasma VL for >= 5 years.Results. At PHI baseline, higher CD8 cell counts were associated with more recent infection (P =.02), higher CD4 cell counts (P