Quantitative detection of trace perfluorinated compounds in environmental water samples by Matrix-assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry with 1,8-bis(tetramethylguanidino)-naphthalene as matrix
Quantitative detection of trace perfluorinated compounds in environmental water samples by Matrix-assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry with 1,8-bis(tetramethylguanidino)-naphthalene as matrix
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以1,8-双(四甲基胍)-萘为基质的基质辅助激光解吸/电离-飞行时间质谱法定量检测环境水样中的痕量全氟化合物
DOI：
10.1016/j.talanta.2011.03.062
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发表时间：
2011-07-15
期刊：
影响因子：
6.1
通讯作者：
Kang, Yuehui
中科院分区：
文献类型：
--
作者：
Cao, Dong;Wang, Zhidong;Kang, Yuehui
全氟化合物(PFC)的检测非常重要，因为它们对环境和人类健康都有潜在的危害。本工作首次以超碱性质子海绵1，8-双(四甲基胍)-萘(TMGN)为基质，采用基质辅助激光解吸电离飞行时间质谱仪(MALDI-TOF-MS)定量检测环境水样中的酸性全氟碳化物。选择全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)等几种酸性全氟碳化物作为模型分析物，验证了该检测方法的可行性。结果表明，在没有任何其他基质离子干扰的情况下，这些PFC的去质子化离子被检测到。TMGN检测全氟辛烷磺酸的灵敏度比MALDI-TOF-MS检测脂肪酸的1，8-二(二甲氨基)萘(DMAN)高10倍。该方法灵敏度高，可用于复杂环境水样中酸性全氟碳化物的监测和定量。此外，建立了固相萃取-MALDI-TOF-MS联用检测环境水样中全氟辛烷化合物的新方法。线性范围宽(全氟辛烷磺酸、全氟辛烷磺酸和全氟辛烷磺酸的线性范围为0.1~10 ng L-1，全氟辛烷磺酸、全氟辛烷磺酸和全氟辛烷磺酸的线性范围为0.5~5 0 ng L-1)。得到了。该方法对全氟辛烷磺酸的检出限为0.015 ng L-1(信噪比为3)，低于高压液相色谱-串联质谱仪(LC-MS/MS)的检出限(0.036 ng L-1)。此外，将该方法应用于小清河和高碑店污水水样中PFC的检测。所获得的全氟碳化合物的浓度与LC-MS/MS方法得到的结果接近。结果表明，以TMGN为基质的MALDI-TOF-MS方法具有较高的可靠性，可作为环境水样中痕量全氟碳化物检测的一种替代方法。(C)2011爱思唯尔B.V.保留所有权利。
Determination of perfluorinated compounds (PFCs) is very important because of their potential hazards to the environment and human health. In present work, 1,8-bis (tetramethylguanidino)-naphthalene (TMGN), a superbasic proton sponge, was firstly employed as the matrix for quantitative detection of acidic PFCs in environmental water samples by Matrix-assisted Laser Desorption/lonization-Time of Flight Mass Spectrometry (MALDI-TOF-MS). Several acidic PFCs, such as perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA), were selected as model analytes for demonstrating the feasibility of the detection method. The results showed that deprotonated ions of these PFCs were detected without any other matrix ions interference. The achieved sensitivity with TMGN for PFOS detection was ten-fold higher than that with 1,8-bis (dimethyl-amino)-naphthalene (DMAN) which was used for the detection of fatty acid by MALDI-TOF-MS. The high sensitivity of this method made it feasible to monitor and quantify acidic PFCs in complicated environmental water samples. Furthermore, a novel combined strategy of solid phase extraction (SPE) followed by MALDI-TOF-MS detection was developed for quantifying PFCs in environmental water samples. The calibration curves with a wide linear dynamic range (0.1-10 ng L-1 for PFOS, PFHxS, and PFBS, and 0.5-50 ng L-1 for PFOA, PFNA, and PFDA.) were obtained. The limit of detection CLOD) for PFOS of this method was 0.015 ng L-1 (a signal-to-noise ratio of 3), which was lower than the LOD (0.036 ng L-1) obtained by high-pressure liquid chromatography/tandem mass spectrometry (LC-MS/MS) method. Moreover, the strategy was used to detect the selected PFCs in water samples collected from Xiaoqinghe river and Gaobeidian wastewater. The achieved concentrations of PFCs were closed to those obtained by LC-MS/MS method. It is indicated that the proposed MALDI-TOF-MS method with TMGN as the matrix is much reliable and can be used as an alternative method to detect trace PFCs in environmental water samples. (C) 2011 Elsevier B.V. All rights reserved.