DEMONSTRATION OF INTERLEUKIN-2, INTERLEUKIN-4 AND INTERLEUKIN-6 IN SERA FROM PATIENTS WITH LOCALIZED SCLERODERMA
DEMONSTRATION OF INTERLEUKIN-2, INTERLEUKIN-4 AND INTERLEUKIN-6 IN SERA FROM PATIENTS WITH LOCALIZED SCLERODERMA
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DOI：
10.1007/bf01262331
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发表时间：
1995-02-01
影响因子：
3
通讯作者：
TAKEHARA, K
中科院分区：
文献类型：
--
作者：
IHN, H;SATO, S;TAKEHARA, K
据报道，局限性硬皮病伴有与 B 细胞相关的免疫学异常，但对该疾病中 T 细胞的激活知之甚少。在这项研究中，使用敏感的酶联免疫吸附测定法测定了 48 名局限性硬皮病患者和 20 名全身性硬皮病患者的血清白细胞介素 4 (IL-2)、白细胞介素 4 (IL-4) 和白细胞介素 6 (IL-6)（已知这些物质是由活化的 T 细胞释放）的水平。硬化症，以及 20 名健康对照受试者。在局限性硬皮病患者的血清中检测到 IL-2、IL-4 和 IL-6，但在健康对照的血清中未检测到。抗组蛋白抗体的存在与 IL-4 和 IL-6 水平升高显着相关。 IL-2、IL-4 和 IL-6 血清水平的降低与皮肤硬化的改善并行。局限性硬皮病患者血清中频繁检测到这些淋巴因子反映了这种疾病中 T 细胞的激活。
Localized scleroderma has been reported to be accompanied by immunological abnormalities related to B cells, but little is known about T-cell activation in this disease, In this study, serum levels of interleukin-4 (IL-2), interleukin-4 (IL-4) and interleukin-6 (IL-6), which are known to be released by activated T cells, were determined using a sensitive enzyme-linked immunosorbent assay in 48 patients with localized scleroderma and 20 with systemic sclerosis, and in 20 healthy control subjects. IL-2, IL-4 and IL-6 were detected in serum from patients with localized scleroderma but not in that from healthy controls. The presence of antihistone antibodies correlated significantly with elevated IL-4 and IL-6 levels. Decreased serum levels of IL-2, IL-4 and IL-6 paralleled improvement in cutaneous sclerosis. Frequent detection of these lymphokines in serum from patients with localized scleroderma reflects T-cell activation in this disorder.