Enhancement of β-endorphin levels in rat hypothalamus by exercise
Enhancement of β-endorphin levels in rat hypothalamus by exercise
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DOI：
10.7600/jspfsm1949.52.159
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发表时间：
2003-04-01
影响因子：
--
通讯作者：
Sato, M
中科院分区：
文献类型：
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作者：
Asahina, S;Asano, K;Sato, M
研究了运动对大鼠下丘脑和血浆内源性β -内啡肽（BE）和皮质类固醇（CS）水平的影响。5周龄雄性大鼠F344只，分为三组：不自主运动组（IE）、非运动组（NE）和对照组(C)。IE组每天以20 m/min的速度运动1小时，连续7 ~ 28天。训练后，取大鼠下丘脑和血浆。采用大鼠BE ELISA试剂盒检测下丘脑水溶性提取物中BE的含量；用RIA检测血浆CS含量。IE组大鼠下丘脑中BE的含量明显高于NE和C组。虽然运动7天、14天和21天的大鼠之间没有显著差异，但运动28天的大鼠下丘脑的BE水平明显高于运动7天的大鼠。NE大鼠下丘脑BE含量与C大鼠基本相同。另一方面，血浆CS水平无明显变化。这些结果可能表明，运动，尤其是跑步，会导致下丘脑中BE水平的增加。
The influence of exercise on the endogenous levels of both beta-endorphin (BE) and corticosteroid (CS) in the hypothalamus and plasma was examined in rats. F344 male rats, five weeks of age, were divided into three groups: involuntary exercised (IE), non-exercised (NE) and control (C) groups. Rats in the IE group were exercised every day for one hour at the speed of 20 m/min for 7 to 28 days. After training, the hypothalamus and plasma were obtained from rats. BE levels in water soluble extracts of hypothalamus were examined by rat BE ELISA test kits; and CS contents in plasma was examined by RIA. The amount of BE in the hypothalamus obtained from rats in the IE group was much higher than that in the NE and C groups. Although there was no significant difference between rats exercised for 7, 14, and 21 days, BE levels in the hypothalamus from rats exercised for 28 days was significantly higher than for 7 days. The amount of BE in the hypothalamus of NE rats was nearly identical to that of C rats. On the other hand, there were no significant changes in plasma CS levels. These results may suggest that exercise, especially running, causes on increase in BE levels in the hypothalamus.