A Temperature-Sensitive Liposomal 1H CEST and 19F Contrast Agent for MR Image-Guided Drug Delivery

A Temperature-Sensitive Liposomal 1H CEST and 19F Contrast Agent for MR Image-Guided Drug Delivery
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DOI:
10.1021/ja8087532
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发表时间:
2009-02-04
影响因子:
15
通讯作者:
Gruell, Holger
Gruell, Holger
中科院分区:
化学1区
文献类型:
--
作者:
Langereis, Sander;Keupp, Jochen;Gruell, Holger

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一种新型的温度敏感脂质体。MRI造影剂已经开发出来,它允许使用H-1 CEST定位药物载体,同时使用F-19 MR成像来定量药物释放,以响应局部温度升高。
A novel temperature-sensitive liposomal. MRI contrast agent has been developed, which allows drug carrier localization using H-1 CEST with simultaneous quantification of the drug release using F-19 MR imaging in response to a local temperature increase.