Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS: a meta-analysis.
Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS: a meta-analysis.
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DOI：
10.1097/qad.0000000000000922
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Dubrow R
中科院分区：
文献类型：
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作者：
Park LS;Hernández-Ramírez RU;Silverberg MJ;Crothers K;Dubrow R
艾滋病毒/艾滋病感染者的癌症负担是巨大的，而且还在不断增加。我们评估了自2000年以来西方高收入国家成人艾滋病患者中可改变的癌症危险因素的流行情况。荟萃分析。我们检索了PubMed，以确定2011-2013年发表的报告PLWHA人群中吸烟、饮酒、超重/肥胖以及感染人乳头瘤病毒（HPV）、丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）的文章。我们对每个危险因素的流行率进行了随机效应荟萃分析，包括总体、性别特异性和hiv传播群体特异性流行率的估计。我们比较了美国成年人中PLWHA的患病率与公布的患病率估计值。荟萃分析包括113篇出版物。总体总结患病率估计为当前吸烟，54%(95%可信区间（CI） 49%-59%)，而美国成年人为20-23%；宫颈高危HPV感染46% (95% CI 34%-58%)，而美国女性为29%；口腔高危HPV感染，16% (95% CI 10%-23%)，美国成人为4%；肛门高危HPV感染（男男性行为者），68% (95% CI 57%-79%)，无比较估计；慢性丙型肝炎病毒感染，26% (95% CI 21%-30%)，美国成人为0.9%；HBV感染为5% (95% CI 4-5%)，而美国成人为0.3%。超重/肥胖患病率（53%;95% CI 46%-59%）低于美国成年人（68%）。不同的评估方法阻碍了对酒精消费流行率的荟萃分析。总的来说，我们观察到在患病率估计中有相当大的研究异质性。艾滋病毒感染者中吸烟和致癌病毒感染的流行率仍然非常高，表明迫切需要努力减少危险因素。
The burden of cancer among persons living with HIV/AIDS (PLWHA) is substantial and increasing. We assessed the prevalence of modifiable cancer risk factors among adult PLWHA in Western high-income countries since 2000. Meta-analysis. We searched PubMed to identify articles published in 2011-2013 reporting prevalence of smoking, alcohol consumption, overweight/obesity, and infection with human papillomavirus (HPV), hepatitis C virus (HCV) and hepatitis B virus (HBV) among PLWHA. We conducted random effects meta-analyses of prevalence for each risk factor, including estimation of overall, sex-specific, and HIV-transmission-group-specific prevalence. We compared prevalence in PLWHA with published prevalence estimates in US adults. The meta-analysis included 113 publications. Overall summary prevalence estimates were current smoking, 54% (95% confidence interval (CI) 49%-59%) versus 20-23% in US adults; cervical high-risk HPV infection, 46% (95% CI 34%-58%) versus 29% in US females; oral high-risk HPV infection, 16% (95% CI 10%-23%) versus 4% in US adults; anal high-risk HPV infection (men who have sex with men), 68% (95% CI 57%-79%), with no comparison estimate available; chronic HCV infection, 26% (95% CI 21%-30%) versus 0.9% in US adults; and HBV infection, 5% (95% CI 4-5%) versus 0.3% in US adults. Overweight/obesity prevalence (53%; 95% CI 46%-59%) was below that of US adults (68%). Meta-analysis of alcohol consumption prevalence was impeded by varying assessment methods. Overall, we observed considerable study heterogeneity in prevalence estimates. Prevalence of smoking and oncogenic virus infections continues to be extraordinarily high among PLWHA, indicating a vital need for risk factor reduction efforts.