Polyphenol-enriched azuki bean (Vina angularis) extract reduces the oxidative stress and prevents DNA oxidation in the hearts of streptozotocin-induced early diabetic rats
Polyphenol-enriched azuki bean (Vina angularis) extract reduces the oxidative stress and prevents DNA oxidation in the hearts of streptozotocin-induced early diabetic rats
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DOI：
10.1080/09637486.2019.1576598
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发表时间：
2019-02
影响因子：
3.9
通讯作者：
Tomomi Kita-Tomihara;Shin Sato;Shojiro Yamasaki;Yukako Ueno;Goh Kimura;R. M. Ketema;T. Kawahara;M. Kurasaki;T. Saito
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文献类型：
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作者：
Tomomi Kita-Tomihara;Shin Sato;Shojiro Yamasaki;Yukako Ueno;Goh Kimura;R. M. Ketema;T. Kawahara;M. Kurasaki;T. Saito
本文观察了链脲佐菌素(STZ)诱导的糖尿病早期大鼠心脏的变化，以及赤豆提取物(ABE)是否能影响这些变化。实验糖尿病组大鼠灌胃0或40 mg/kg的Abe，连续4周，对照组灌胃蒸馏水。检测8-羟基-2‘-脱氧鸟苷(8-OHdG)、过氧化体FAβ氧化相关蛋白的表达及氧化应激标志物。糖尿病组过氧化物酶ACOX1和过氧化氢酶水平显著高于对照组。STZ组p62、磷酸化p62(p-p62)和HO-1水平显著高于对照组，ABE治疗组p-p62、HO-1和8-OHdG水平显著低于对照组。链脲佐菌素诱导的早期糖尿病增加了心脏中与过氧化体FA、β氧化和氧化应激标志物相关的蛋白质水平。安倍保护糖尿病人的心脏免受氧化损伤。
Abstract We examined the changes in the heart of rats at the early stages of streptozotocin (STZ)-induced diabetes, and whether azuki bean extract (ABE) could influence these changes. The experimental diabetic rats received 0 or 40 mg/kg of ABE orally for 4 weeks, whereas the control group rats received distilled water. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and expression of proteins associated with peroxisomal FA β-oxidation as well as oxidative stress markers were examined. The levels of peroxisomal ACOX1 and catalase of the diabetic groups were significantly higher than those in the control group. The levels of p62, phosphorylated-p62 (p-p62) and HO-1 in the STZ group were significantly higher than those in the control group, and the levels of p-p62, HO-1, and 8-OHdG were significantly lower by ABE administration. The STZ-induced early diabetes increases the levels of proteins related to peroxisomal FA β-oxidation and oxidative stress markers in hearts. ABE protects diabetic hearts from oxidative damage.