Amyloids protect the silkmoth oocyte and embryo
Amyloids protect the silkmoth oocyte and embryo
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DOI：
10.1016/s0014-5793(00)01888-3
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发表时间：
2000-08-18
期刊：
影响因子：
3.5
通讯作者：
Hamodrakas, SJ
中科院分区：
文献类型：
--
作者：
Iconomidou, VA;Vriend, G;Hamodrakas, SJ
绒毛膜是蚕蛾蛋壳的主要成分。其95%以上的干质量由蛋白质组成，具有显著的机械和化学特性，保护卵母细胞和发育中的胚胎免受各种环境危害。我们提供的数据来自电子显微镜（阴性染色和阴影）、x射线衍射和蚕蛾绒毛膜蛋白合成肽类似物的建模研究，表明绒毛膜是一种天然的淀粉样蛋白。绒毛膜肽的折叠和自组装模型强烈支持最近由Blake和serbell提出的淀粉样蛋白原纤维的β -片螺旋模型[Structure 4 (1996) 989-998], (C) 2000年欧洲生化学会联合会。Elsevier Science B.V.版权所有。
Chorion is the major component of silkmoth eggshell. More than 95%, of its dry mass consists of proteins that have remarkable mechanical and chemical properties protecting the oocyte and the developing embryo from a wide range of environmental hazards. We present data from electron microscopy (negative staining and shadowing), X-ray diffraction and modeling studies of synthetic peptide analogues of silkmoth chorion proteins indicating that chorion is a natural amyloid, The folding and self-assembly models of chorion peptides strongly support the beta-sheet helix model of amyloid fibrils proposed recently by Blake and Serpell [Structure 4 (1996) 989-998], (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.