Self-replication: spelling it out in a chemical background

Self-replication: spelling it out in a chemical background
复制标题

自我复制:在化学背景下拼出它

DOI:
10.1007/s12064-010-0117-5
复制
发表时间:
2011-06
影响因子:
1.1
通讯作者:
Zhou, Ping
Zhou, Ping
中科院分区:
生物学4区
文献类型:
--
作者:
Yu, Chunwu;Hu, Jiming;Ma, Wentao;Zhang, Wentao;Zhou, Ping

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自我复制是从生命的关键特征生殖中抽象出来的一个重要概念,其定义模糊,其化学机制也缺乏明确的解释。在关于生命的本质及其起源的讨论中,这个模糊的概念经常被提及,它引起了许多不确定的陈述、混淆的参考和不当的辩论,并严重阻碍了这一领域的努力。在本文中,我们试图在更基本和更清晰的背景下通过概念分析来改善这种情况。在物质世界中,自我复制只能意味着“一个实体倾向于自己的生产”。这种偏向作用的主要化学机制是催化作用,可分为速度偏向和方向偏向两种类型(模板导向功能实际上是一种方向偏向的催化作用)。分子的自我复制可以基于自催化或自我代谢;复杂实体的自我复制可以基于自催化和/或自我代谢集,并且应该涉及自我分裂机制。这种概念上的澄清阐明了关于生命本质及其起源的模糊领域。
Self-replication, an important concept abstracted from reproduction, the key feature of life, remains vague in definition and lacking in clear interpretation in terms of its chemical mechanism. Mentioned frequently in discussions concerning the essence of life and its origin, the vague concept has caused a lot of uncertain statements, confusable references, and malposed debates, and has seriously held back efforts in this field. In this article, we try to improve the situation by a conceptual analysis in a more fundamental and clearer background. Self-replication in the substantial world could not mean anything but that “an entity favors the production of its own.” The major chemical mechanism for such favoring is catalysis, which can be classified into speed- and direction-favoring types (the template-directing function is actually a type of direction-favoring catalysis). Molecular self-replication could be based on autocatalysis or self-metabolism; the self-replication of a complex entity could be based on autocatalytic and/or self-metabolic sets, and should involve a mechanism of self-division. This conceptual clarification sheds light on the dim areas concerning the essence of life and its origin.
DOI: 10.1002/qua.560140722
发表时间: 2009-06
期刊: Physics Letters B
影响因子: 4.4
作者:
M. Eigen;P. Schuster
通讯作者: M. Eigen;P. Schuster
DOI: 10.1101/087969380.24.1
发表时间: 1993
期刊: Cold Spring Harbor Monograph Archive
影响因子: --
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DOI: 10.1023/a:1026663422976
发表时间: 2000-11-01
期刊: MOLECULAR BIOLOGY
影响因子: 1.2
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DOI: 10.3891/acta.chem.scand.50-0469
发表时间: 1996
期刊: Acta Chemica Scandinavica
影响因子: --
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