Effect of cimetidine on the absorption of vitamin B12.
Effect of cimetidine on the absorption of vitamin B12.
复制标题
西咪替丁对维生素B12吸收的影响。
DOI：
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发表时间：
1982
影响因子：
1.9
通讯作者：
A. Doscherholmen
中科院分区：
文献类型：
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作者：
I. Salom;S. Silvis;A. Doscherholmen
在13例患者中研究了西咪替丁对口服晶体或食物（蛋黄结合）维生素B12 （B12）吸收的影响。吸收或结晶B12正常，西咪替丁未显著改变。相比之下，所有患者的食源性B12摄取量都下降了，从未服用药物的平均5.3%下降到服用药物后的2.5%，下降了53% （p < 0.0001）。这种对B12吸收的损害增加了长期全剂量西咪替丁治疗可能导致B12缺乏的可能性，类似于在其他次氯酸状态下所见的情况。我们的数据表明，标准的希林试验无法检测到西咪替丁诱导的B12吸收不良。
The effect of cimetidine on the absorption of orally administered crystalline or food (egg yolk-bound) vitamin B12 (B12) was studied in 13 patients. Absorption or crystalline B12 was normal and not significantly changed by cimetidine. In contrast, the uptake of food-bound B12 decreased in all patients, from a mean of 5.3% without the drug to 2.5% after it, a fall of 53% (p less than 0.0001). This impairment of B12 absorption raises the possibility that long-term, full-dose therapy with cimetidine may produce B12 deficiency similar to that seen in other hypochlorhydric states. Our data indicate that cimetidine-induced B12 malabsorption would not be detected by the standard Schilling test.