Clinical and microbiological effects of ozone nano-bubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial
Clinical and microbiological effects of ozone nano-bubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial
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DOI：
10.1007/s00784-012-0711-7
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发表时间：
2013-03-01
影响因子：
3.4
通讯作者：
Izumi, Yuichi
中科院分区：
文献类型：
--
作者：
Hayakumo, Sae;Arakawa, Shinichi;Izumi, Yuichi
臭氧纳米气泡水（NBW3）似乎是适合作为牙周治疗的辅助剂，由于其有效的抗菌效果，高水平的安全性和长期的储存稳定性。本研究的目的是评估NBW3冲洗作为牙周治疗龈下清创术的辅助手段的临床和微生物学效果。22名受试者被随机分配到两个治疗组之一：全口机械清创术与自来水（WATER）或全口机械清创术与NBW3（NBW3）。在基线和治疗后4周和8周进行临床检查。治疗前、治疗后即刻、治疗后1周、8周进行微生物检查，4周后两组各项临床指标均有明显改善。NBW3组在4周和8周后的探测袋深度和临床附着增加的减少显著大于WATER组。此外，只有NBW3组的龈下菌斑中的平均细菌总数在统计学上显着减少，在研究periods.The本研究表明，龈下冲洗与NBW3可能是一个有价值的辅助牙周治疗。这项研究验证了新的抗菌剂，MNW 3，作为牙周治疗的辅助的潜力。
Ozone nano-bubble water (NBW3) seems to be suitable as an adjunct to periodontal treatment owing to its potent antimicrobial effects, high level of safety, and long storage stability. The aim of the present study was to evaluate the clinical and microbiological effects of NBW3 irrigation as an adjunct to subgingival debridement for periodontal treatment.Twenty-two subjects were randomly assigned to one of the two treatment groups: full-mouth mechanical debridement with tap water (WATER) or full-mouth mechanical debridement with NBW3 (NBW3). Clinical examination was performed at baseline and 4 and 8 weeks after treatment. Microbiological examination was carried out just before and after treatment and at 1 and 8 weeks posttreatment.There were significant improvements in all clinical parameters after 4 weeks in both groups. The reduction in the probing pocket depth and the clinical attachment gain after 4 and 8 weeks in the NBW3 group were significantly greater than those in the WATER group. Moreover, only the NBW3 group showed statistically significant reductions in the mean total number of bacteria in subgingival plaque over the study period.The present study suggests that subgingival irrigation with NBW3 may be a valuable adjunct to periodontal treatment.This study verified the potential of new antimicrobial agent, MNW3, as an adjunct to periodontal treatment.