Is amyloid-β harmful to the brain? Insights from human imaging studies
Is amyloid-β harmful to the brain? Insights from human imaging studies
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DOI：
10.1093/brain/awv326
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发表时间：
2016-01-01
期刊：
影响因子：
14.5
通讯作者：
Jagust, William
中科院分区：
文献类型：
--
作者：
Jagust, William
Although the amyloid-beta protein associated with the Alzheimer's disease plaque has been detectable in living people for over a decade, its importance in the pathogenesis of Alzheimer's disease is still debated. The frequent presence of amyloid-beta in the brains of cognitively healthy older people has been interpreted as evidence against a causative role. If amyloid-beta is crucial to the development of Alzheimer's disease, it should be associated with other Alzheimer's disease-like neurological changes. This review examines whether amyloid-beta is associated with other biomarkers indicative of early Alzheimer's disease in normal older people. The preponderance of evidence links amyloid-beta to functional change, progressive brain atrophy, and cognitive decline. Individuals at greatest risk of decline seem to be those with evidence of both amyloid-beta and findings suggestive of neurodegeneration. The crucial question is thus how amyloid-beta is related to brain degeneration and how these two processes interact to cause cognitive decline and dementia.
