'O-Acyl isopeptide method' for the efficient synthesis of difficult sequence-containing peptides:: use of 'O-acyl isodipeptide unit'
'O-Acyl isopeptide method' for the efficient synthesis of difficult sequence-containing peptides:: use of 'O-acyl isodipeptide unit'
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DOI：
10.1016/j.tetlet.2006.03.017
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发表时间：
2006-05-01
影响因子：
1.8
通讯作者：
Kiso, Y
中科院分区：
文献类型：
--
作者：
Sohma, Y;Taniguchi, A;Kiso, Y
A novel 'O-acyl isodipeptide unit', Boc-Thr(Fmoe-Val)-OH 5 has been successfully used for the efficient synthesis of a difficult sequence-containing pentapeptide based on the 'O-acyl isopeptide method', in which racemization-inducible esterification could be omitted, suggesting that the use Of O-acyl isodipeptide units allows the application of this method to fully automated protocols for the synthesis of long peptides or proteins. (c) 2006 Elsevier Ltd. All rights reserved.
