Cleveland Clinic Cognitive Battery (C3B): Normative, Reliability, and Validation Studies of a Self-Administered Computerized Tool for Screening Cognitive Dysfunction in Primary Care.
Cleveland Clinic Cognitive Battery (C3B): Normative, Reliability, and Validation Studies of a Self-Administered Computerized Tool for Screening Cognitive Dysfunction in Primary Care.
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DOI：
10.3233/jad-220929
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发表时间：
2023
影响因子：
4
通讯作者：
Posk, Lori
中科院分区：
文献类型：
--
作者：
Rao, Stephen M.;Galioto, Rachel;Sokolowski, Megan;Pierce, Madelyn;Penn, Lisa;Sturtevant, Anna;Skugor, Blazenka;Anstead, Brent;Leverenz, James B.;Schindler, David;Blum, David;Alberts, Jay L.;Posk, Lori
关键词：
自我管理的基于ipad的克利夫兰诊所认知电池（C3B）是专门为初级保健环境中老年人认知功能的有效筛查而设计的。1)从健康参与者中生成基于回归的规范，以便进行人口统计修正，以促进临床解释；2)评估重测信度和实践效果；3)检测轻度认知障碍（MCI）与健康衰老的区分能力；4) d在分散的临床环境中确定筛查的有效性；5)确定初级保健环境中的完成率和患者满意度。研究1 （S1）招募了428名年龄在18-89岁的健康成年人作为分层样本，生成基于回归的方程。S2评估30例健康老年人2周重测信度和实践效果。S3招募了30名轻度认知障碍患者和30名人口统计学匹配的健康对照。在S4中，30名健康的老年人在一个分散注意力的环境和一个安静的私人房间中以平衡的顺序自行服用C3B。在一个示范项目中，470名连续的初级保健患者被给予C3B作为常规临床护理的一部分（S5）。C3B表现主要受年龄、教育和种族（S1）的影响，具有可接受的高重测信度和最小的实践效应（S2），将MCI与健康对照区分开来（S3），不受分散的临床环境（S4）的负面影响，具有高完成率（>92%）和初级保健患者的正面评价（S5）。C3B是一种可靠、有效、自我管理的计算机化认知筛查工具，有助于整合到繁忙的初级保健临床工作流程中，用于检测MCI、早期阿尔茨海默病和其他相关痴呆。
The self-administered iPad-based Cleveland Clinic Cognitive Battery (C3B) was designed specifically for the efficient screening of cognitive functioning of older adults in a primary care setting. 1) Generate regression-based norms from healthy participants to enable demographic corrections to facilitate clinical interpretation; 2) estimate test-retest reliability and practice effects; 3) examine ability to discriminate mild cognitive impairment (MCI) from healthy aging; 4) d etermine validity of screening in a distracting clinical environment; and 5) determine completion rates and patient satisfaction in a primary care setting. Study 1 (S1) recruited a stratified sample of 428 healthy adults, ages 18–89, to generate regression-based equations. S2 assessed 2-week test-retest reliability and practice effects in 30 healthy elders. S3 recruited 30 MCI patients and 30 demographically-matched healthy controls. In S4, 30 healthy elders self-administered the C3B in a distracting environment and in a quiet private room in counterbalanced order. In a demonstration project, 470 consecutive primary care patients were administered the C3B as part of routine clinical care (S5). C3B performance was primarily influenced by age, education, and race (S1), had acceptably high test-retest reliability and minimal practice effects (S2), discriminated MCI from healthy controls (S3), was not negatively impacted by a distracting clinical environment (S4), had high completion rates (>92%) and positive ratings from primary care patients (S5). The C3B is a computerized cognitive screening tool that is reliable, validated, self-administered, and is conducive to integration into a busy primary care clinical workflow for detecting MCI, early Alzheimer’s disease, and other related dementias.