Vasectomy increases the severity of diet-induced atherosclerosis in Macaca fascicularis.
Vasectomy increases the severity of diet-induced atherosclerosis in Macaca fascicularis.
复制标题
输精管结扎术增加了食蟹猴饮食引起的动脉粥样硬化的严重程度。
作者：
N. Alexander;T. Clarkson
饮食诱导的动脉粥样硬化在输精管结扎术的食蟹猴(猕猴)中比在喂食相同食物的假输精管结扎术的对照组猴子中发生得更广泛。这种影响在腹主动脉、颈动脉、冠状动脉远端段和颅内脑动脉最为明显。在所有输精管结扎的猴子中都产生了精子抗体，在一些输精管结扎的动物中，补体和免疫球蛋白与动脉粥样硬化斑块有关。对精子抗原的免疫反应经常伴随着输精管结扎术，可能会加剧动脉粥样硬化。
Diet-induced atherosclerosis developed more extensively in vasectomized cynomolgus monkeys (Macaca fascicularis) than in sham-vasectomized control monkeys fed the same diet. The effect was most pronounced in the abdominal aortas, carotid arteries, distal segments of the coronary arteries, and intracranial cerebral arteries. Antibodies to sperm developed in all vasectomized monkeys, and complement and immunoglobulins were associated with atherosclerotic plaques in some of the vasectomized animals. The immunological response to sperm antigens that often accompanies vasectomy may exacerbate atherosclerosis.