Noninvasive Differentiation of Simple Steatosis and Steatohepatitis by Using Gadoxetic Acid-enhanced MR Imaging in Patients with Nonalcoholic Fatty Liver Disease: A Proof-of-Concept Study
Noninvasive Differentiation of Simple Steatosis and Steatohepatitis by Using Gadoxetic Acid-enhanced MR Imaging in Patients with Nonalcoholic Fatty Liver Disease: A Proof-of-Concept Study
复制标题
DOI：
10.1148/radiol.14131890
复制
发表时间：
2014-06-01
期刊：
影响因子：
19.7
通讯作者：
Ba-Ssalamah, Ahmed
中科院分区：
文献类型：
--
作者：
Bastati, Nina;Feier, Diana;Ba-Ssalamah, Ahmed
Purpose: To determine whether gadoxetic acid-enhanced magnetic resonance (MR) imaging can be used to distinguish between simple steatosis and nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD), defined according to the steatosis activity and fibrosis (SAF) scoring system, which is based on the semi-quantitative scoring of steatosis activity and liver fibrosis.Materials and Methods: The local institutional review committee approved this study and waived written informed consent. This was a retrospective study of gadoxetic acid-enhanced 3-T MR imaging performed in 81 patients with NAFLD (45 men [56%]; mean age, 56 years; range, 25-78 years). The MR images were analyzed by using the relative enhancement (the ratio of signal intensities of the liver parenchyma before and 20 minutes after intravenous administration of gadoxetic acid). Univariate and multiple regression analyses were applied to identify variables associated with relative enhancement measurements. The ability of relative enhancement to allow differentiation between simple steatosis and NASH was assessed by using area under the receiver operating characteristic (ROC) curve analysis.Results: Relative enhancement negatively correlated with the degree of lobular inflammation (r = -0.59, P < .0001), ballooning (r = -0.44, P < .0001), and fibrosis (r = -0.59, P
